EC Number |
Natural Substrates |
---|
1.16.1.1 | Hg + NAD+ + H+ |
- |
1.16.1.1 | Hg + NADP+ + H+ |
- |
1.16.1.1 | Hg + NADP+ + H+ |
MerA catalyzes the bioconversion of toxic Hg2+ to the least toxic elemental Hg0, and is capable of reducing the Hg2+, via NADPH as an electron donor |
1.16.1.1 | Hg + NADP+ + H+ |
organomercurials are converted to less toxic Hg(0) in the cytosol by the sequential action of organomercurial lyase MerB and mercuric ion reductase MerA, requiring transfer of Hg(II) from MerB to MerA, with transfer to the metallochaperone-like NmerA domain as the kinetically favored pathway in this coevolved system, overview |
1.16.1.1 | Hg + NADP+ + H+ |
the enzmye reduces reactive Hg2+ to volatile and relatively inert monoatomic Hg0 vapor. Pseudomonas putida SP1 is able to volatilize almost 100% of the total mercury it is exposed to |
1.16.1.1 | Hg2+ + NADPH |
- |
1.16.1.1 | Hg2+ + NADPH |
inducible enzyme |
1.16.1.1 | Hg2+ + NADPH |
mercury resistance is due to the sequential action of two mercury-detoxificating enzymes, organomercurial lyase and mercuric reductase. Enzyme is induced by Hg2+ and organomercurials |
1.16.1.1 | Hg2+ + NADPH |
last step in bacterial mercury detoxification pathway |
1.16.1.1 | Hg2+ + NADPH |
the enzyme is a key component of an organomercurial detoxification system |