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EC Number
Inhibitors
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Structure
2.3.2.B11
Calmodulin
UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine motif. Deletion of the motif (amino acids 29-58) results in loss of calmodulin binding and a significant increase in the in vitro ubiquitylation activity of UBE3B. Changes in calcium levels in vitro disrupt the calmodulin-UBE3B interaction
2.3.2.B11
EGTA
-
2.3.2.B11
Trifluoperazine
0.03 mM
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