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Literature summary extracted from

  • Liu, Q.; Liu, Y.; Kang, Z.; Xiao, D.; Gao, C.; Xu, P.; Ma, C.
    2,3-Butanediol catabolism in Pseudomonas aeruginosa PAO1 (2018), Environ. Microbiol., 20, 3927-3940 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.4 genetic structure of the 2,3-BD utilization operon in Pseudomonas aeruginosa strain PAO1 and comparisons, overview Pseudomonas aeruginosa
1.1.1.B20 genetic structure of the 2,3-BD utilization operon in Pseudomonas aeruginosa strain PAO1 and comparisons, overview Pseudomonas aeruginosa
1.1.1.76 genetic structure of the 2,3-BD utilization operon in Pseudomonas aeruginosa strain PAO1 and comparisons, overview Pseudomonas aeruginosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.4 0.057
-
(2R,3R)-butane-2,3-diol pH 7.4, 30°C Pseudomonas aeruginosa
1.1.1.B20 0.128
-
(2R,3S)-butane-2,3-diol pH 7.4, 30°C Pseudomonas aeruginosa
1.1.1.76 0.024
-
(2S,3S)-butane-2,3-diol pH 7.4, 30°C Pseudomonas aeruginosa
2.3.1.190 0.055
-
acetoin pH 7.4, 30°C Pseudomonas aeruginosa
2.3.1.190 0.483
-
diacetyl pH 7.4, 30°C Pseudomonas aeruginosa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.4 Zn2+ zinc binding enzyme Pseudomonas aeruginosa
1.1.1.B20 Zn2+ zinc binding enzyme Pseudomonas aeruginosa
1.1.1.76 Zn2+ zinc binding enzyme Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa ATCC 15692
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa 1C
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa PRS 101
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa DSM 22644
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa CIP 104116
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa LMG 12228
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa JCM 14847
-
(3R)-acetoin + NADH + H+
-
?
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa
-
(R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa ATCC 15692
-
(R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa 1C
-
(R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa PRS 101
-
(R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa DSM 22644
-
(R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa CIP 104116
-
(R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa LMG 12228
-
(R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa JCM 14847
-
(R)-acetoin + NADH + H+
-
r
1.1.1.B20 (2R,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa meso-butane-2,3-diol (3R)-acetoin + NADH + H+
-
?
1.1.1.B20 (R,R)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa
-
(R)-acetoin + NADH + H+
-
r
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa
-
(S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa ATCC 15692
-
(S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa 1C
-
(S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa PRS 101
-
(S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa DSM 22644
-
(S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa CIP 104116
-
(S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa LMG 12228
-
(S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ Pseudomonas aeruginosa JCM 14847
-
(S)-acetoin + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.4 Pseudomonas aeruginosa Q9HWM8
-
-
1.1.1.4 Pseudomonas aeruginosa 1C Q9HWM8
-
-
1.1.1.4 Pseudomonas aeruginosa ATCC 15692 Q9HWM8
-
-
1.1.1.4 Pseudomonas aeruginosa CIP 104116 Q9HWM8
-
-
1.1.1.4 Pseudomonas aeruginosa DSM 22644 Q9HWM8
-
-
1.1.1.4 Pseudomonas aeruginosa JCM 14847 Q9HWM8
-
-
1.1.1.4 Pseudomonas aeruginosa LMG 12228 Q9HWM8
-
-
1.1.1.4 Pseudomonas aeruginosa PRS 101 Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa 1C Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa ATCC 15692 Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa CIP 104116 Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa DSM 22644 Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa JCM 14847 Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa LMG 12228 Q9HWM8
-
-
1.1.1.B20 Pseudomonas aeruginosa PRS 101 Q9HWM8
-
-
1.1.1.76 Pseudomonas aeruginosa
-
-
-
1.1.1.76 Pseudomonas aeruginosa 1C
-
-
-
1.1.1.76 Pseudomonas aeruginosa ATCC 15692
-
-
-
1.1.1.76 Pseudomonas aeruginosa CIP 104116
-
-
-
1.1.1.76 Pseudomonas aeruginosa DSM 22644
-
-
-
1.1.1.76 Pseudomonas aeruginosa JCM 14847
-
-
-
1.1.1.76 Pseudomonas aeruginosa LMG 12228
-
-
-
1.1.1.76 Pseudomonas aeruginosa PRS 101
-
-
-
2.3.1.190 Pseudomonas aeruginosa Q9HWN1 AND Q9HWN0 Q9HWN1: AcoA, Q9HWN0: AcoB
-
2.3.1.190 Pseudomonas aeruginosa ATCC 15692 Q9HWN1 AND Q9HWN0 Q9HWN1: AcoA, Q9HWN0: AcoB
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.190
-
Pseudomonas aeruginosa

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.4 0.155
-
pH 7.4, 30°C, substrate propane-1,2-diol Pseudomonas aeruginosa
1.1.1.4 0.331
-
pH 7.4, 30°C, substrate 1-hydroxy-2-butanone Pseudomonas aeruginosa
1.1.1.4 0.383
-
pH 7.4, 30°C, substrate butane-1,2-diol Pseudomonas aeruginosa
1.1.1.4 1.179
-
pH 7.4, 30°C, substrate (2R,3S)-butane-2,3-diol Pseudomonas aeruginosa
1.1.1.4 1.346
-
pH 7.4, 30°C, substrate 2,3-pentanedione Pseudomonas aeruginosa
1.1.1.4 1.538
-
pH 7.4, 30°C, substrate (2R,3R)-butane-2,3-diol Pseudomonas aeruginosa
1.1.1.4 1.949
-
pH 7.4, 30°C, substrate rac acetoin Pseudomonas aeruginosa
1.1.1.4 2.154
-
pH 7.4, 30°C, substrate diacetyl Pseudomonas aeruginosa
1.1.1.B20 0.155
-
pH 7.4, 30°C, substrate propane-1,2-diol Pseudomonas aeruginosa
1.1.1.B20 0.331
-
pH 7.4, 30°C, substrate 1-hydroxy-2-butanone Pseudomonas aeruginosa
1.1.1.B20 0.383
-
pH 7.4, 30°C, substrate butane-1,2-diol Pseudomonas aeruginosa
1.1.1.B20 1.179
-
pH 7.4, 30°C, substrate (2R,3S)-butane-2,3-diol Pseudomonas aeruginosa
1.1.1.B20 1.346
-
pH 7.4, 30°C, substrate 2,3-pentanedione Pseudomonas aeruginosa
1.1.1.B20 1.538
-
pH 7.4, 30°C, substrate (2R,3R)-butane-2,3-diol Pseudomonas aeruginosa
1.1.1.B20 1.949
-
pH 7.4, 30°C, substrate rac acetoin Pseudomonas aeruginosa
1.1.1.B20 2.154
-
pH 7.4, 30°C, substrate diacetyl Pseudomonas aeruginosa
1.1.1.76 0.194
-
pH 7.4, 30°C, substrate butane-1,2-diol Pseudomonas aeruginosa
1.1.1.76 0.516
-
pH 7.4, 30°C, substrate 2-butanol Pseudomonas aeruginosa
1.1.1.76 0.779
-
pH 7.4, 30°C, substrate propane-1,2-diol Pseudomonas aeruginosa
1.1.1.76 0.84
-
pH 7.4, 30°C, substrate (2S,3S)-butane-2,3-diol Pseudomonas aeruginosa
1.1.1.76 1.671
-
pH 7.4, 30°C, substrate n-butanal Pseudomonas aeruginosa
1.1.1.76 1.837
-
pH 7.4, 30°C, substrate 1-hydroxy-2-butanone Pseudomonas aeruginosa
1.1.1.76 3.238
-
pH 7.4, 30°C, substrate rac acetoin Pseudomonas aeruginosa
1.1.1.76 7.28
-
pH 7.4, 30°C, substrate 2,3-pentanedione Pseudomonas aeruginosa
1.1.1.76 8.286
-
pH 7.4, 30°C, substrate diacetyl Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa ATCC 15692 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa ATCC 15692 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa 1C (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa 1C (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa PRS 101 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa PRS 101 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa DSM 22644 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa DSM 22644 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa CIP 104116 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa CIP 104116 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa LMG 12228 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa LMG 12228 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa JCM 14847 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa JCM 14847 (3R)-acetoin + NADH + H+
-
?
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa ATCC 15692 (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa 1C (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa PRS 101 (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa DSM 22644 (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa CIP 104116 (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa LMG 12228 (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa JCM 14847 (R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa (3R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa ATCC 15692 (3R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa 1C (3R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa PRS 101 (3R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa DSM 22644 (3R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa CIP 104116 (3R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa LMG 12228 (3R)-acetoin + NADH + H+
-
r
1.1.1.4 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa JCM 14847 (3R)-acetoin + NADH + H+
-
r
1.1.1.4 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa ? + NAD+
-
?
1.1.1.4 2,3-pentandione + NADH + H+
-
Pseudomonas aeruginosa ? + NAD+
-
?
1.1.1.4 butane-1,2-diol + NAD+
-
Pseudomonas aeruginosa ? + NADH + H+
-
?
1.1.1.4 diacetyl + 2 NADH + 2 H+
-
Pseudomonas aeruginosa (2R,3R)-butane-2,3-diol + 2 NAD+
-
r
1.1.1.4 diacetyl + NADH + H+
-
Pseudomonas aeruginosa (3R)-acetoin + NAD+
-
r
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa ?
-
-
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa ATCC 15692 ?
-
-
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa 1C ?
-
-
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa PRS 101 ?
-
-
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa DSM 22644 ?
-
-
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa CIP 104116 ?
-
-
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa LMG 12228 ?
-
-
1.1.1.4 additional information no activity with (2S,3S)-2,3-butane-2,3-diol, but the (2R,3R)-2,3-butanediol dehydrogenase is also active with meso-2,3-butanediol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa JCM 14847 ?
-
-
1.1.1.4 propane-1,2-diol + NAD+
-
Pseudomonas aeruginosa ? + NADH + H+
-
?
1.1.1.4 rac acetoin + NADH + H+
-
Pseudomonas aeruginosa (2R,3R)-butane-2,3-diol + NAD+
-
?
1.1.1.4 rac acetoin + NADH + H+
-
Pseudomonas aeruginosa (2R,3S)-butane-2,3-diol + NAD+
-
?
1.1.1.B20 (2R,3S)-butane-2,3-diol + NAD+ meso-butane-2,3-diol Pseudomonas aeruginosa (3R)-acetoin + NADH + H+
-
?
1.1.1.B20 (2R,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa (3R)-acetoin + NADH + H+
-
?
1.1.1.B20 (R,R)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa (R)-acetoin + NADH + H+
-
r
1.1.1.B20 (R,R)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa (3R)-acetoin + NADH + H+
-
r
1.1.1.B20 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa ? + NAD+
-
?
1.1.1.B20 2,3-pentandione + NADH + H+
-
Pseudomonas aeruginosa ? + NAD+
-
?
1.1.1.B20 butane-1,2-diol + NAD+
-
Pseudomonas aeruginosa ? + NADH + H+
-
?
1.1.1.B20 diacetyl + 2 NADH + 2 H+
-
Pseudomonas aeruginosa (2R,3R)-butane-2,3-diol + 2 NAD+
-
r
1.1.1.B20 diacetyl + NADH + H+
-
Pseudomonas aeruginosa (3R)-acetoin + NAD+
-
r
1.1.1.B20 additional information the (2R,3R)-2,3-butanediol dehydrogenase is active with (R,R)-butane-2,3-diol, but also with meso-butane-2,3-diol, but not with with (2S,3S)-2,3-butane-2,3-diol. No activity with 2-butanol, 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. And no activity with 2,4-pentanedione, butanone, 2,5-hexanedione, n-butanal and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2R,3R)-2,3-BDH reduces diacetyl into (3R)-acetoin and (2R,3R)-2,3-BD, while racemic acetoin is reduced into (2R,3R)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa ?
-
-
1.1.1.B20 propane-1,2-diol + NAD+
-
Pseudomonas aeruginosa ? + NADH + H+
-
?
1.1.1.B20 rac acetoin + NADH + H+
-
Pseudomonas aeruginosa (2R,3R)-butane-2,3-diol + NAD+
-
?
1.1.1.B20 rac acetoin + NADH + H+
-
Pseudomonas aeruginosa (2R,3S)-butane-2,3-diol + NAD+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa ATCC 15692 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa ATCC 15692 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa 1C (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa 1C (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa PRS 101 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa PRS 101 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa DSM 22644 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa DSM 22644 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa CIP 104116 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa CIP 104116 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa LMG 12228 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa LMG 12228 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+
-
Pseudomonas aeruginosa JCM 14847 (S)-acetoin + NADH + H+
-
?
1.1.1.76 (2S,3S)-butane-2,3-diol + NAD+ stereoselective interconversion Pseudomonas aeruginosa JCM 14847 (S)-acetoin + NADH + H+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa ? + NAD+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa ATCC 15692 ? + NAD+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa 1C ? + NAD+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa PRS 101 ? + NAD+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa DSM 22644 ? + NAD+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa CIP 104116 ? + NAD+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa LMG 12228 ? + NAD+
-
?
1.1.1.76 1-hydroxy-2-butanone + NADH + H+
-
Pseudomonas aeruginosa JCM 14847 ? + NAD+
-
?
1.1.1.76 2 diacetyl + 2 NADH + 2 H+
-
Pseudomonas aeruginosa (3S)-acetoin + (2S,3S)-butane-2,3-diol + NAD+
-
?
1.1.1.76 2 rac acetoin + 2 NADH + 2 H+
-
Pseudomonas aeruginosa (2S,3S)-butane-2,3-diol + (2R,3S)-butane-2,3-diol + 2 NAD+
-
?
1.1.1.76 2,3-pentandione + NADH + H+
-
Pseudomonas aeruginosa ? + NAD+
-
?
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa 2-butanone + NADH + H+
-
ir
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa ATCC 15692 2-butanone + NADH + H+
-
ir
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa 1C 2-butanone + NADH + H+
-
ir
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa PRS 101 2-butanone + NADH + H+
-
ir
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa DSM 22644 2-butanone + NADH + H+
-
ir
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa CIP 104116 2-butanone + NADH + H+
-
ir
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa LMG 12228 2-butanone + NADH + H+
-
ir
1.1.1.76 2-butanol + NAD+
-
Pseudomonas aeruginosa JCM 14847 2-butanone + NADH + H+
-
ir
1.1.1.76 butane-1,2-diol + NAD+
-
Pseudomonas aeruginosa ? + NADH + H+
-
?
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa ?
-
-
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa ATCC 15692 ?
-
-
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa 1C ?
-
-
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa PRS 101 ?
-
-
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa DSM 22644 ?
-
-
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa CIP 104116 ?
-
-
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa LMG 12228 ?
-
-
1.1.1.76 additional information no activity with (2R,3R)-butane-2,3-diol and (2R,3S)-butane-2,3-diol, and no activity with 1,3-butanediol, 1,2-pentanediol, 1,3-propanediol, and glycerol in the oxidation reaction. No activity with 2,4-pentanedione, butanone, 2,5-hexanedione, and 1,3-dihydroxypropanone in the reduction reaction. Substrate specificity, overview. (2S,3S)-2,3-BDH reduces diacetyl into (3S)-acetoin and (2S,3S)-2,3-BD, while racemic acetoin is reduced to form (2S,3S)-2,3-BD and meso-2,3-BD Pseudomonas aeruginosa JCM 14847 ?
-
-
1.1.1.76 n-butanal + NADH + H+
-
Pseudomonas aeruginosa ? + NAD+
-
?
1.1.1.76 propane-1,2-diol + NAD+
-
Pseudomonas aeruginosa ? + NADH + H+
-
?
2.3.1.190 acetoin + CoA + NAD+
-
Pseudomonas aeruginosa acetaldehyde + acetyl-CoA + NADH + H+
-
?
2.3.1.190 acetoin + CoA + NAD+
-
Pseudomonas aeruginosa ATCC 15692 acetaldehyde + acetyl-CoA + NADH + H+
-
?
2.3.1.190 diacetyl + CoA + NAD+
-
Pseudomonas aeruginosa ?
-
?
2.3.1.190 diacetyl + CoA + NAD+
-
Pseudomonas aeruginosa ATCC 15692 ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.4 (2R,3R)-2,3-BDH
-
Pseudomonas aeruginosa
1.1.1.4 (2R,3R)-2,3-butanediol dehydrogenase
-
Pseudomonas aeruginosa
1.1.1.4 BDH
-
Pseudomonas aeruginosa
1.1.1.4 More cf. EC 1.1.1.303 Pseudomonas aeruginosa
1.1.1.4 PA4153 locus name Pseudomonas aeruginosa
1.1.1.B20 BDH
-
Pseudomonas aeruginosa
1.1.1.B20 More cf. EC 1.1.1.303 Pseudomonas aeruginosa
1.1.1.B20 PA4153 locus name Pseudomonas aeruginosa
1.1.1.76 (2R,3R)-2,3-BDH
-
Pseudomonas aeruginosa
1.1.1.76 (2R,3R)-2,3-butanediol dehydrogenase
-
Pseudomonas aeruginosa
1.1.1.76 BDH
-
Pseudomonas aeruginosa
1.1.1.76 More cf. EC 1.1.1.304 Pseudomonas aeruginosa
2.3.1.190 acetoin dehydrogenase enzyme system consists of TPP-dependent acetoin dehydrogenase (AoDH E1), dihydrolipoamide acetyltransferase (AoDH E2) and dihydrolipoamide dehydrogenase (AoDH E3) Pseudomonas aeruginosa
2.3.1.190 AcoAB
-
Pseudomonas aeruginosa
2.3.1.190 PA4150
-
Pseudomonas aeruginosa
2.3.1.190 PA4151
-
Pseudomonas aeruginosa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.4 30
-
assay at Pseudomonas aeruginosa
1.1.1.B20 30
-
assay at Pseudomonas aeruginosa
1.1.1.76 30
-
assay at Pseudomonas aeruginosa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.4 7.4
-
assay at Pseudomonas aeruginosa
1.1.1.B20 7.4
-
assay at Pseudomonas aeruginosa
1.1.1.76 7.4
-
assay at Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.4 NAD+
-
Pseudomonas aeruginosa
1.1.1.4 NADH
-
Pseudomonas aeruginosa
1.1.1.B20 NAD+
-
Pseudomonas aeruginosa
1.1.1.B20 NADH
-
Pseudomonas aeruginosa
1.1.1.76 NAD+
-
Pseudomonas aeruginosa
1.1.1.76 NADH
-
Pseudomonas aeruginosa
2.3.1.190 thiamine diphosphate enzyme is dependent on Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
1.1.1.4 malfunction the amount of (2R,3R)-2,3-BD is highly reduced in a DELTAacoR mutant lacking the regulatory protein AcoR. The loss of locus pa4153, encoding (2R,3R)-2,3-BDH, has no effect on the ability of this strain to grow in (2S,3S)-2,3-BD but completely impairs its ability to utilize (2R,3R)-2,3-BD and meso-2,3-BD. The complementation of the pa4153 mutant strain with its gene successfully restores the growth ability. The DELTApa4153 PAO1 strain can grow in racemic acetoin, indicating that (2R,3R)-2,3-BDH contributes to 2,3-BD utilization by converting 2,3-BD into acetoin Pseudomonas aeruginosa
1.1.1.4 physiological function 22,3-butanediol (2,3-BD) exists in three stereoisomeric forms: (2R,3R)-2,3-BD, meso-2,3-BD and (2S,3S)-2,3-BD. All three stereoisomers are transformed into acetoin by (2R,3R)-2,3-butanediol dehydrogenase (BDH) or (2S,3S)-2,3-BDH. Acetoin is cleaved to form acetyl-CoA and acetaldehyde by acetoin dehydrogenase enzyme system (AoDH ES). Genes encoding (2R,3R)-2,3-BDH, (2S,3S)-2,3-BDH and the E1 and E2 components of AoDH ES are identified as part of a 2,3-BD utilization operon. In addition, the regulatory protein AcoR promotes the expression of this operon using acetaldehyde, a cleavage product of acetoin, as its direct effector. Proposed model for 2,3-BD utilization in Pseudomonas aeruginosa strain PAO1 in downstream catabolic pathways, overview. Genes pa4148, pa4149, pa4150, pa4151, pa4152 and pa4153 comprise an operon responsible for 2,3-BD utilization, mutational analysis. Acetaldehyde is the direct inducer of the 2,3-BD utilization operon Pseudomonas aeruginosa
1.1.1.B20 malfunction the amount of meso-2,3-BD is highly reduced in a DELTAacoR mutant lacking the regulatory protein AcoR. The loss of locus pa4153, encoding (2R,3R)-2,3-BDH, has no effect on the ability of this strain to grow in (2S,3S)-2,3-BD but completely impairs its ability to utilize (2R,3R)-2,3-BD and meso-2,3-BD. The complementation of the pa4153 mutant strain with its gene successfully restores the growth ability. The DELTApa4153 PAO1 strain can grow in racemic acetoin, indicating that (2R,3R)-2,3-BDH contributes to 2,3-BD utilization by converting 2,3-BD into acetoin Pseudomonas aeruginosa
1.1.1.B20 metabolism 2,3-butanediol (2,3-BD) exists in three stereoisomeric forms: (2R,3R)-2,3-BD, meso-2,3-BD and (2S,3S)-2,3-BD. All three stereoisomers are transformed into acetoin by (2R,3R)-2,3-butanediol dehydrogenase (BDH) or (2S,3S)-2,3-BDH. Acetoin is cleaved to form acetyl-CoA and acetaldehyde by acetoin dehydrogenase enzyme system (AoDH ES). Genes encoding (2R,3R)-2,3-BDH, (2S,3S)-2,3-BDH and the E1 and E2 components of AoDH ES are identified as part of a 2,3-BD utilization operon. In addition, the regulatory protein AcoR promotes the expression of this operon using acetaldehyde, a cleavage product of acetoin, as its direct effector. Proposed model for 2,3-BD utilization in Pseudomonas aeruginosa strain PAO1 in downstream catabolic pathways, overview. Genes pa4148, pa4149, pa4150, pa4151, pa4152 and pa4153 comprise an operon responsible for 2,3-BD utilization, mutational analysis. Acetaldehyde is the direct inducer of the 2,3-BD utilization operon Pseudomonas aeruginosa
1.1.1.B20 physiological function 2,3-butanediol (2,3-BD) is a primary microbial metabolite that enhances the virulence of Pseudomonas aeruginosa and alters the lung microbiome. 2,3-BD exists in three stereoisomeric forms: (2R,3R)-2,3-BD, meso-2,3-BD and (2S,3S)-2,3-BD Pseudomonas aeruginosa
1.1.1.76 malfunction the amount of (2S,3S)-2,3-BD is highly reduced in a DELTAacoR mutant lacking the regulatory protein AcoR. The disruption of locus pa4148, encoding (2S,3S)-2,3-BDH, partially impairs the growth of this strain in (2S,3S)-2,3-BD but does not affect its growth in (2R,3R)-2,3-BD and meso-2,3-BD. The complementation of the pa4148 mutant strain with its gene successfully restores the growth ability. The DELTApa4148 PAO1 strain can grow in racemic acetoin, indicating that (2S,3S)-2,3-BDH contributes to 2,3-BD utilization by converting 2,3-BD into acetoin Pseudomonas aeruginosa
1.1.1.76 metabolism 2,3-butanediol (2,3-BD) exists in three stereoisomeric forms: (2R,3R)-2,3-BD, meso-2,3-BD and (2S,3S)-2,3-BD. All three stereoisomers are transformed into acetoin by (2R,3R)-2,3-butanediol dehydrogenase (BDH) or (2S,3S)-2,3-BDH. Acetoin is cleaved to form acetyl-CoA and acetaldehyde by acetoin dehydrogenase enzyme system (AoDH ES). Genes encoding (2R,3R)-2,3-BDH, (2S,3S)-2,3-BDH and the E1 and E2 components of AoDH ES are identified as part of a 2,3-BD utilization operon. In addition, the regulatory protein AcoR promotes the expression of this operon using acetaldehyde, a cleavage product of acetoin, as its direct effector. Proposed model for 2,3-BD utilization in Pseudomonas aeruginosa strain PAO1 in downstream catabolic pathways, overview. Genes pa4148, pa4149, pa4150, pa4151, pa4152 and pa4153 comprise an operon responsible for 2,3-BD utilization, mutational analysis. Acetaldehyde is the direct inducer of the 2,3-BD utilization operon Pseudomonas aeruginosa
1.1.1.76 physiological function 2,3-butanediol (2,3-BD) is a primary microbial metabolite that enhances the virulence of Pseudomonas aeruginosa and alters the lung microbiome. 2,3-BD exists in three stereoisomeric forms: (2R,3R)-2,3-BD, meso-2,3-BD and (2S,3S)-2,3-BD Pseudomonas aeruginosa
2.3.1.190 malfunction acoA, acoB are knocked out individually in Pseudomonas aeruginosa PAO1. The mutants lose the ability to grow in acetoin or 2,3-butanediol Pseudomonas aeruginosa
2.3.1.190 metabolism the enzyme is involved in 2,3-butanediol catabolism Pseudomonas aeruginosa