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Literature summary extracted from

  • Hasanuzzaman, M.; Yoshimura, M.
    Effects of straight chain alcohols on specific isoforms of adenylyl cyclase (2010), Alcohol. Clin. Exp. Res., 34, 743-749.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 1,2,3-propanetriol isoform AC6 shows about 10% stimulation of activity with 100 mM 1,2,3-propanetriol, isoform AC7 shows about 18% stimulation of activity with 100 mM 1,2,3-propanetriol, isoform AC9 shows about 15% stimulation of activity with 100 mM 1,2,3-propanetriol Homo sapiens
4.6.1.1 1,2-Butanediol isoform AC6 shows about 37% stimulation of activity with 100 mM 1,2-butanediol, isoform AC7 shows about 38% stimulation of activity with 100 mM 1,2-butanediol, isoform AC9 shows about 32% stimulation of activity with 100 mM 1,2-butanediol Homo sapiens
4.6.1.1 1,3-butanediol isoforms AC6 and AC7 show about 22% stimulation of activity with 100 mM 1,3-butanediol, isoform AC9 shows about 17% stimulation of activity with 100 mM 1,3-butanediol Homo sapiens
4.6.1.1 1,3-Propanediol isoform AC6 shows about 17% stimulation of activity with 100 mM 1,3-propanediol, isoform AC7 shows about 20% stimulation of activity with 100 mM 1,3-propanediol, isoform AC9 shows about 17% stimulation of activity with 100 mM 1,3-propanediol Homo sapiens
4.6.1.1 1,4-Butanediol isoform AC6 shows about 30% stimulation of activity with 100 mM 1,4-butanediol, isoform AC7 shows about 25% stimulation of activity with 100 mM 1,4-butanediol, isoform AC9 shows about 40% stimulation of activity with 100 mM 1,4-butanediol Homo sapiens
4.6.1.1 1-butanol isoform AC6 shows about 85% stimulation of activity with 100 mM 1-butanol, isoform AC7 shows about 110% stimulation of activity with 100 mM 1-butanol, isoform AC9 shows about 105% stimulation of activity with 100 mM 1-butanol Homo sapiens
4.6.1.1 1-propanol isoform AC6 shows about 31% stimulation of activity with 100 mM 1-propanol, isoform AC7 shows about 50% stimulation of activity with 100 mM 1-propanol, isoform AC9 shows about 44% stimulation of activity with 100 mM 1-propanol Homo sapiens
4.6.1.1 2,3-Butanediol isoform AC6 shows about 30% stimulation of activity with 100 mM 2,3-butanediol, isoform AC7 shows about 35% stimulation of activity with 100 mM 2,3-butanediol, isoform AC9 shows about 41% stimulation of activity with 100 mM 2,3-butanediol Homo sapiens
4.6.1.1 2-butanol isoform AC6 shows about 60% stimulation of activity with 100 mM 2-butanol, isoform AC7 shows about 70% stimulation of activity with 100 mM 2-butanol, isoform AC9 shows about 60% stimulation of activity with 100 mM 2-butanol Homo sapiens
4.6.1.1 2-propanol isoform AC6 shows about 20% stimulation of activity with 100 mM 2-propanol, isoform AC7 shows about 35% stimulation of activity with 100 mM 2-propanol, isoform AC9 shows about 40% stimulation of activity with 100 mM 2-propanol Homo sapiens
4.6.1.1 D-(-)-2,3-butanediol isoforms AC6 and AC7show about 30% stimulation of activity with 100 mM D-(-)-2,3-butanediol, isoform AC9 shows about 10% stimulation of activity with 100 mM D-(-)-2,3-butanediol Homo sapiens
4.6.1.1 D1A dopamine receptor
-
 Homo sapiens
4.6.1.1 ethanol stimulates isoform AC6, AC7 and AC9 activity Homo sapiens
4.6.1.1 L-(+)-2,3-butanediol isoform AC6 shows about 55% stimulation of activity with 100 mM L-(+)-2,3-butanediol, isoform AC9 shows about 45% stimulation of activity with 100 mM L-(+)-2,3-butanediol Homo sapiens
4.6.1.1 meso-2,3-butanediol isoform AC6 shows about 15% stimulation of activity with 100 mM meso-2,3-butanediol, isoform AC7 shows about 28% stimulation of activity with 100 mM meso-2,3-butanediol, isoform AC9 shows about 10% stimulation of activity with 100 mM meso-2,3-butanediol Homo sapiens
4.6.1.1 additional information isoforms AC6, AC7 and AC9 are not significantly stimulated by 1,2,4-butanetriol and 1,2,3,4-butanetetraol Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 L-(+)-2,3-butanediol isoform AC7 activity is inhibited to about 50% with 100 mM L-(+)-2,3-butanediol Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC6 isoform Homo sapiens
4.6.1.1 AC7 isoform Homo sapiens
4.6.1.1 AC9 isoform Homo sapiens
4.6.1.1 adenylyl cyclase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.6.1.1 Calmodulin
-
 Homo sapiens