Activating Compound | Comment | Organism | Structure |
---|---|---|---|
SIRT5 | an NAD-dependent SIR2 deacetylase homologue, is involved in deacetylation and activation of carbamoyl phosphate synthetase 1, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of SIRT5 in mice leads to increased deacetylation and activation of CPS1 protein in liver of transgenic mice compared to wild-type mice. Urea production is upregulated in hepatocytes of SIRT5 transgenic mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + NH3 + CO2 + H2O | Mus musculus | - |
2 ADP + phosphate + carbamoyl phosphate | - |
? | |
2 ATP + NH3 + CO2 + H2O | Mus musculus C57BL/6 | - |
2 ADP + phosphate + carbamoyl phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
acetylation | mitochondrial CPSI is acetylated, and activated by deacetylation through SIRT5, overview | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + NH3 + CO2 + H2O | - |
Mus musculus | 2 ADP + phosphate + carbamoyl phosphate | - |
? | |
2 ATP + NH3 + CO2 + H2O | - |
Mus musculus C57BL/6 | 2 ADP + phosphate + carbamoyl phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carbamoyl phosphate synthetase 1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | CPS1 is a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate | Mus musculus |