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Literature summary for 6.3.4.16 extracted from

  • Butler, S.L.; Dong, H.; Cardona, D.; Jia, M.; Zheng, R.; Zhu, H.; Crawford, J.M.; Liu, C.
    The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1 (2008), Lab. Invest., 88, 78-88.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information the urea cycle enzyme CPS1 is the antigen for Hep Par 1 antibody Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
166000
-
mass spectrometry Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NH3 + CO2 + H2O Homo sapiens CPS1 is a rate-limiting enzyme in the urea cycle ADP + phosphate + carbamoyl phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell hepatocarcinoma cell line, suppression of CPS1 expression occurs at the transcriptional level Homo sapiens
-
hepatoma cell hepatoid tumors of gastric and yolk sac Homo sapiens
-
Huh-7 cell hepatocarcinoma cell line, suppression of CPS1 expression occurs at the transcriptional level Homo sapiens
-
LH-86 cell hepatocarcinoma cell line, suppression of CPS1 expression occurs at the transcriptional level Homo sapiens
-
liver
-
Homo sapiens
-
additional information no expression in gallbladder, thyroid, spleen, kidney, and skin, immunohistochemic analysis, overview, CPS1 expression is suppressed at the transcriptional level in human hepatocellular carcinoma cell lines Homo sapiens
-
small intestine
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NH3 + CO2 + H2O
-
Homo sapiens ADP + phosphate + carbamoyl phosphate
-
?
ATP + NH3 + CO2 + H2O CPS1 is a rate-limiting enzyme in the urea cycle Homo sapiens ADP + phosphate + carbamoyl phosphate
-
?

Synonyms

Synonyms Comment Organism
carbamoyl phosphate synthetase 1
-
Homo sapiens
CPS1
-
Homo sapiens
p165
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens sequence calculation
-
6.3