Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.1.1 extracted from

  • Pareek, V.; Samanta, M.; Joshi, N.V.; Balaram, H.; Murthy, M.R.; Balaram, P.
    Connecting active-site loop conformations and catalysis in triosephosphate isomerase Insights from a rare variation at residue 96 in the plasmodial enzyme (2016), ChemBioChem, 17, 620-629 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
F96A considerable loss in acitivity Plasmodium falciparum
F96S 300fold drop in kcat/Km Plasmodium falciparum
F96S/L167V considerable loss in acitivity Plasmodium falciparum
F96S/S73A considerable loss in acitivity Plasmodium falciparum
F96Y considerable loss in acitivity Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.35
-
D-glyceraldehyde 3-phosphate wild-type, 25°C, pH not specified in the publication Plasmodium falciparum
0.87
-
D-glyceraldehyde 3-phosphate mutant F96A, 25°C, pH not specified in the publication Plasmodium falciparum
1.02
-
D-glyceraldehyde 3-phosphate mutant F96S/L167V, 25°C, pH not specified in the publication Plasmodium falciparum
1.2
-
D-glyceraldehyde 3-phosphate mutant F96S/S73A, 25°C, pH not specified in the publication Plasmodium falciparum
1.85
-
D-glyceraldehyde 3-phosphate mutant F96Y, 25°C, pH not specified in the publication Plasmodium falciparum
2.2
-
D-glyceraldehyde 3-phosphate mutant F96S, 25°C, pH not specified in the publication Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q07412
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate
-
Plasmodium falciparum dihydroxyacetone 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
TIM
-
Plasmodium falciparum
TpI
-
Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.8
-
D-glyceraldehyde 3-phosphate mutant F96A, 25°C, pH not specified in the publication Plasmodium falciparum
4
-
D-glyceraldehyde 3-phosphate mutant F96S/L167V, 25°C, pH not specified in the publication Plasmodium falciparum
4.3
-
D-glyceraldehyde 3-phosphate wild-type, 25°C, pH not specified in the publication Plasmodium falciparum
4.6
-
D-glyceraldehyde 3-phosphate mutant F96S/S73A, 25°C, pH not specified in the publication Plasmodium falciparum
5.5
-
D-glyceraldehyde 3-phosphate mutant F96Y, 25°C, pH not specified in the publication Plasmodium falciparum
6.2
-
D-glyceraldehyde 3-phosphate mutant F96S, 25°C, pH not specified in the publication Plasmodium falciparum

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
28
-
D-glyceraldehyde 3-phosphate mutant F96S, 25°C, pH not specified in the publication Plasmodium falciparum
30
-
D-glyceraldehyde 3-phosphate mutant F96Y, 25°C, pH not specified in the publication Plasmodium falciparum
38
-
D-glyceraldehyde 3-phosphate mutant F96S/S73A, 25°C, pH not specified in the publication Plasmodium falciparum
390
-
D-glyceraldehyde 3-phosphate mutant F96S/L167V, 25°C, pH not specified in the publication Plasmodium falciparum
440
-
D-glyceraldehyde 3-phosphate mutant F96A, 25°C, pH not specified in the publication Plasmodium falciparum
12000
-
D-glyceraldehyde 3-phosphate wild-type, 25°C, pH not specified in the publication Plasmodium falciparum