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Literature summary for 5.3.1.1 extracted from

  • Lee, W.H.; Choi, J.S.; Byun, M.R.; Koo, K.T.; Shin, S.; Lee, S.K.; Surh, Y.J.
    Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: Potential role of Cdk2 (2010), Toxicology, 278, 224-228.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of TPI in Spodoptera frugiperda Sf21 cells using the baculovirus transfection system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information TPI phosphorylation by cyclin A/Cdk2 kinase leads to reduced TPI activity, prevented by treatment with olomoucine, a specific inhibitor of Cdk2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Glyceraldehyde 3-phosphate Homo sapiens
-
Glycerone phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein TPI is a direct substrate of cyclin-dependent protein kinase 2, Cdk2, during etoposide-induced apoptosis, analysis by MALDI-TOF peptide finger printing. Phosphorylation of the recombinant TPI by recombinant cyclin A/Cdk2 kinase leading to reduced TPI activity, protection by olomoucine, a specific inhibitor of Cdk2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Glyceraldehyde 3-phosphate
-
Homo sapiens Glycerone phosphate
-
?

Synonyms

Synonyms Comment Organism
TpI
-
Homo sapiens
Triosephosphate isomerase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in glycolysis Homo sapiens