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Literature summary for 5.3.1.1 extracted from
- Interaction of triosephosphate isomerase from the cell surface of Staphylococcus aureus and alpha-(1->3)-mannooligosaccharides derived from glucuronoxylomannan of Cryptococcus neoformans (2009), Microbiology, 155, 2707-2713.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| mannobiose | - |
Staphylococcus aureus |  |
| Mannopentaose | - |
Staphylococcus aureus | |
| Mannotetraose | - |
Staphylococcus aureus | |
| Mannotriose | docking simulation | Staphylococcus aureus | |
| additional information | stronger inhibition by alpha-(1,3)-mannooligosaccharides than with triose, binding constants, overview | Staphylococcus aureus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Staphylococcus aureus | 9986 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
x * 30000, about, SDS-PAGE | Staphylococcus aureus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glyceraldehyde 3-phosphate | Staphylococcus aureus | - |
Glycerone phosphate | - |
? | |
| D-Glyceraldehyde 3-phosphate | Staphylococcus aureus RN4220 | - |
Glycerone phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
| Staphylococcus aureus RN4220 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme 2400fold from cell surface by hydrophobic interaction and anion exchange chromatography, followed by adsorption chromatography | Staphylococcus aureus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 13000 | - |
purified native enzyme | Staphylococcus aureus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glyceraldehyde 3-phosphate | - |
Staphylococcus aureus | Glycerone phosphate | - |
? | |
| D-Glyceraldehyde 3-phosphate | - |
Staphylococcus aureus RN4220 | Glycerone phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 30000, about, SDS-PAGE | Staphylococcus aureus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TpI | - |
Staphylococcus aureus |
| Triosephosphate isomerase | - |
Staphylococcus aureus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | TPI of Staphylococcus aureus is a candidate adhesion molecule for the interaction between the bacterium and the fungal pathogen Cryptococcus neoformans. TPI may recognize the mannan backbone of glucuronoxylomannan of Cryptococcus neoformans | Staphylococcus aureus |
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