Any feedback?
Literature summary for 4.2.1.1 extracted from
- In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II (2008), Bioorg. Med. Chem., 16, 9101-9105.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-methylsalicylic acid | noncompetitive inhibition of isozyme carbonic anhydrase I and uncompetitive inhibition of isozyme carbonic anhydrase II | Homo sapiens |  |
| 4,6-dinitrosalicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
| 4-aminosalicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
| 4-sulfosalicylic acid | uncompetitive inhibition of isozyme carbonic anhydrase I and competitive inhibition of isozyme carbonic anhydrase II | Homo sapiens | |
| 5-chlorosalicylic acid | uncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
| 5-sulfosalicylic acid | competitive inhibition of isozyme carbonic anhydrase I and noncompetitive inhibition of isozyme carbonic anhydrase II | Homo sapiens | |
| Acetylsalicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
| diflunisal | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
| dinitrosalicylic acid | - |
Homo sapiens | |
| salicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
| sulfasalazine | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CO2 + H2O | Homo sapiens | - |
H2CO3 | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Sepharose-6B-aniline-sulfanilamide affinity column chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
| CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CA I | - |
Homo sapiens |
| CA II | - |
Homo sapiens |
| carbonic anhydrase I | isozyme | Homo sapiens |
| carbonic anhydrase II | isozyme | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00127 | - |
5-chlorosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 0.00416 | - |
5-chlorosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
| 0.00545 | - |
4,6-dinitrosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 0.00687 | - |
sulfasalazine | isozyme carbonic anhydrase I | Homo sapiens | |
| 0.00845 | - |
diflunisal | isozyme carbonic anhydrase I | Homo sapiens | |
| 0.00872 | - |
sulfasalazine | isozyme carbonic anhydrase II | Homo sapiens | |
| 0.00937 | - |
diflunisal | isozyme carbonic anhydrase II | Homo sapiens | |
| 0.01485 | - |
4,6-dinitrosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
| 0.24 | - |
4-aminosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
| 0.48 | - |
4-sulfosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
| 0.62 | - |
salicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
| 0.74 | - |
salicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 0.77 | - |
5-sulfosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
| 1.06 | - |
4-sulfosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 1.23 | - |
4-aminosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 1.92 | - |
5-sulfosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 3.66 | - |
Acetylsalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 7.53 | - |
Acetylsalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
| 10.57 | - |
3-methylsalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
| 11.42 | - |
3-methylsalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00072 | - |
isozyme carbonic anhydrase II | Homo sapiens | 5-chlorosalicylic acid | |
| 0.0027 | - |
isozyme carbonic anhydrase II | Homo sapiens | diflunisal | |
| 0.0028 | - |
isozyme carbonic anhydrase II | Homo sapiens | dinitrosalicylic acid | |
| 0.00304 | - |
isozyme carbonic anhydrase I | Homo sapiens | sulfasalazine | |
| 0.00338 | - |
isozyme carbonic anhydrase I | Homo sapiens | diflunisal | |
| 0.00407 | - |
isozyme carbonic anhydrase I | Homo sapiens | 5-chlorosalicylic acid | |
| 0.00449 | - |
isozyme carbonic anhydrase II | Homo sapiens | sulfasalazine | |
| 0.00764 | - |
isozyme carbonic anhydrase I | Homo sapiens | dinitrosalicylic acid | |
| 0.13 | - |
isozyme carbonic anhydrase I | Homo sapiens | 4-aminosalicylic acid | |
| 0.29 | - |
isozyme carbonic anhydrase I | Homo sapiens | 4-sulfosalicylic acid | |
| 0.29 | - |
isozyme carbonic anhydrase II | Homo sapiens | 5-sulfosalicylic acid | |
| 0.42 | - |
isozyme carbonic anhydrase I | Homo sapiens | 5-sulfosalicylic acid | |
| 0.56 | - |
isozyme carbonic anhydrase I | Homo sapiens | salicylic acid | |
| 0.68 | - |
isozyme carbonic anhydrase II | Homo sapiens | salicylic acid | |
| 0.72 | - |
isozyme carbonic anhydrase II | Homo sapiens | 4-sulfosalicylic acid | |
| 0.75 | - |
isozyme carbonic anhydrase II | Homo sapiens | 4-aminosalicylic acid | |
| 1.16 | - |
isozyme carbonic anhydrase II | Homo sapiens | Acetylsalicylic acid | |
| 2.71 | - |
isozyme carbonic anhydrase I | Homo sapiens | Acetylsalicylic acid | |
| 3.07 | - |
isozyme carbonic anhydrase I | Homo sapiens | 3-methylsalicylic acid | |
| 4.7 | - |
isozyme carbonic anhydrase II | Homo sapiens | 3-methylsalicylic acid | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
