Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-methylsalicylic acid | noncompetitive inhibition of isozyme carbonic anhydrase I and uncompetitive inhibition of isozyme carbonic anhydrase II | Homo sapiens | |
4,6-dinitrosalicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
4-aminosalicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
4-sulfosalicylic acid | uncompetitive inhibition of isozyme carbonic anhydrase I and competitive inhibition of isozyme carbonic anhydrase II | Homo sapiens | |
5-chlorosalicylic acid | uncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
5-sulfosalicylic acid | competitive inhibition of isozyme carbonic anhydrase I and noncompetitive inhibition of isozyme carbonic anhydrase II | Homo sapiens | |
Acetylsalicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
diflunisal | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
dinitrosalicylic acid | - |
Homo sapiens | |
salicylic acid | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens | |
sulfasalazine | noncompetitive inhibition of isozymes carbonic anhydrase I and II | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | Homo sapiens | - |
H2CO3 | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Sepharose-6B-aniline-sulfanilamide affinity column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA I | - |
Homo sapiens |
CA II | - |
Homo sapiens |
carbonic anhydrase I | isozyme | Homo sapiens |
carbonic anhydrase II | isozyme | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00127 | - |
5-chlorosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
0.00416 | - |
5-chlorosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
0.00545 | - |
4,6-dinitrosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
0.00687 | - |
sulfasalazine | isozyme carbonic anhydrase I | Homo sapiens | |
0.00845 | - |
diflunisal | isozyme carbonic anhydrase I | Homo sapiens | |
0.00872 | - |
sulfasalazine | isozyme carbonic anhydrase II | Homo sapiens | |
0.00937 | - |
diflunisal | isozyme carbonic anhydrase II | Homo sapiens | |
0.01485 | - |
4,6-dinitrosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
0.24 | - |
4-aminosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
0.48 | - |
4-sulfosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
0.62 | - |
salicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
0.74 | - |
salicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
0.77 | - |
5-sulfosalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
1.06 | - |
4-sulfosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
1.23 | - |
4-aminosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
1.92 | - |
5-sulfosalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
3.66 | - |
Acetylsalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
7.53 | - |
Acetylsalicylic acid | isozyme carbonic anhydrase I | Homo sapiens | |
10.57 | - |
3-methylsalicylic acid | isozyme carbonic anhydrase II | Homo sapiens | |
11.42 | - |
3-methylsalicylic acid | isozyme carbonic anhydrase I | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00072 | - |
isozyme carbonic anhydrase II | Homo sapiens | 5-chlorosalicylic acid | |
0.0027 | - |
isozyme carbonic anhydrase II | Homo sapiens | diflunisal | |
0.0028 | - |
isozyme carbonic anhydrase II | Homo sapiens | dinitrosalicylic acid | |
0.00304 | - |
isozyme carbonic anhydrase I | Homo sapiens | sulfasalazine | |
0.00338 | - |
isozyme carbonic anhydrase I | Homo sapiens | diflunisal | |
0.00407 | - |
isozyme carbonic anhydrase I | Homo sapiens | 5-chlorosalicylic acid | |
0.00449 | - |
isozyme carbonic anhydrase II | Homo sapiens | sulfasalazine | |
0.00764 | - |
isozyme carbonic anhydrase I | Homo sapiens | dinitrosalicylic acid | |
0.13 | - |
isozyme carbonic anhydrase I | Homo sapiens | 4-aminosalicylic acid | |
0.29 | - |
isozyme carbonic anhydrase I | Homo sapiens | 4-sulfosalicylic acid | |
0.29 | - |
isozyme carbonic anhydrase II | Homo sapiens | 5-sulfosalicylic acid | |
0.42 | - |
isozyme carbonic anhydrase I | Homo sapiens | 5-sulfosalicylic acid | |
0.56 | - |
isozyme carbonic anhydrase I | Homo sapiens | salicylic acid | |
0.68 | - |
isozyme carbonic anhydrase II | Homo sapiens | salicylic acid | |
0.72 | - |
isozyme carbonic anhydrase II | Homo sapiens | 4-sulfosalicylic acid | |
0.75 | - |
isozyme carbonic anhydrase II | Homo sapiens | 4-aminosalicylic acid | |
1.16 | - |
isozyme carbonic anhydrase II | Homo sapiens | Acetylsalicylic acid | |
2.71 | - |
isozyme carbonic anhydrase I | Homo sapiens | Acetylsalicylic acid | |
3.07 | - |
isozyme carbonic anhydrase I | Homo sapiens | 3-methylsalicylic acid | |
4.7 | - |
isozyme carbonic anhydrase II | Homo sapiens | 3-methylsalicylic acid |