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Literature summary for 4.1.2.13 extracted from

  • Kawai, K.; Uemura, M.; Munakata, K.; Takahashi, H.; Haraguchi, N.; Nishimura, J.; Hata, T.; Matsuda, C.; Ikenaga, M.; Murata, K.; Mizushima, T.; Yamamoto, H.; Doki, Y.; Mori, M.
    Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis (2017), Int. J. Oncol., 50, 525-534 .
    View publication on PubMed
Search for more literature for 4.1.2.13

Application

Application Comment Organism
diagnostics for patients with colorectal cancer mRNA expression is a significant prognostic factor for disease-free survival and for overall survival Homo sapiens
medicine the enzyme is a hypoxia-inducible prognostic factor for colorectal cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose 1,6-bisphosphate Homo sapiens
-
 glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P04075
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
DLD-1 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
KM12-SM cell
-
 Homo sapiens
-
LoVo cell
-
 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate
-
 Homo sapiens glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
aldoA
-
 Homo sapiens
fructose-bisphosphate aldolase A
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is upregulated under hypoxic conditions up
Homo sapiens ALDOA expression is upregulated under hypoxic conditions up

General Information

General Information Comment Organism
malfunction enzyme knockdown stops cell cycle progression and enhances apoptosis due to rapid accumulation of reactive oxygen species Homo sapiens
malfunction knockdown of the enzyme stops cell cycle progression and enhances apoptosis due to rapid accumulation of reactive oxygen species Homo sapiens
physiological function enzyme expression is necessary for cancer cells to grow in hypoxic conditions Homo sapiens
physiological function the enzyme is a key regulator of hypoxic adaptation in colorectal cancer cells Homo sapiens
physiological function the enzyme positively regulates the activity of the glycolytic pathway and the epithelial-mesenchymal transition and is necessary for cell cycle progression. It is implicated in colorectal cancer proliferation, sphere formation, therapeutic resistance and invasion Homo sapiens