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Literature summary for 4.1.2.13 extracted from

  • Li, Z.; Liu, Z.; Cho, D.W.; Zou, J.; Gong, M.; Breece, R.M.; Galkin, A.; Li, L.; Zhao, H.; Maestas, G.D.; Tierney, D.L.; Herzberg, O.; Dunaway-Mariano, D.; Mariano, P.S.
    Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase (2011), J. Inorg. Biochem., 105, 509-517.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with ([3-hydroxy-2-oxo-4-[2-(phosphonooxy)ethyl]pyridin-1(2H)-yl]methyl)phosphonic acid, hanging drop vapor diffusion method, using 22% (w/v) polyethylene glycol 3350 and 0.2 M NH4NO3 Giardia intestinalis

Inhibitors

Inhibitors Comment Organism Structure
([3-hydroxy-2-oxo-4-[(phosphonomethoxy)methyl]pyridin-1(2H)-yl]methyl)phosphonic acid
-
Giardia intestinalis
([3-hydroxy-2-oxo-4-[2-(phosphonooxy)ethyl]pyridin-1(2H)-yl]methyl)phosphonic acid
-
Giardia intestinalis
([3-hydroxy-4-[(1R)-1-hydroxy-2-(phosphonooxy)ethyl]-2-oxopyridin-1(2H)-yl]methyl)phosphonic acid
-
Giardia intestinalis
([3-hydroxy-4-[(1S)-1-hydroxy-2-(phosphonooxy)ethyl]-2-oxopyridin-1(2H)-yl]methyl)phosphonic acid
-
Giardia intestinalis
([4,5-dihydroxy-6-[2-(phosphonooxy)ethyl]pyridin-3-yl]methyl)phosphonic acid
-
Giardia intestinalis
2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl dihydrogen phosphate
-
Giardia intestinalis
2-hydroxy-2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl dihydrogen phosphate
-
Giardia intestinalis
tagatose 1,6-bisphosphate
-
Giardia intestinalis
[(3-hydroxy-2-oxopyridin-1(2H)-yl)methyl]phosphonic acid
-
Giardia intestinalis
[2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl]phosphonic acid
-
Giardia intestinalis
[[(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)methoxy]methyl]phosphonic acid
-
Giardia intestinalis
[[3-hydroxy-2-oxo-4-(2-phosphonoethyl)pyridin-1(2H)-yl]methyl]phosphonic acid
-
Giardia intestinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
D-fructose 1,6-bisphosphate at pH 7.5 and 25°C Giardia intestinalis

Organism

Organism UniProt Comment Textmining
Giardia intestinalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate
-
Giardia intestinalis dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
FBPA
-
Giardia intestinalis
Fructose 1,6-bisphosphate aldolase
-
Giardia intestinalis
fructose-1,6-biphosphate aldolase
-
Giardia intestinalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
tagatose 1,6-bisphosphate at pH 7.5 and 25°C Giardia intestinalis
0.01
-
([3-hydroxy-4-[(1S)-1-hydroxy-2-(phosphonooxy)ethyl]-2-oxopyridin-1(2H)-yl]methyl)phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
0.014
-
([3-hydroxy-2-oxo-4-[2-(phosphonooxy)ethyl]pyridin-1(2H)-yl]methyl)phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
0.015
-
([4,5-dihydroxy-6-[2-(phosphonooxy)ethyl]pyridin-3-yl]methyl)phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
0.09
-
([3-hydroxy-4-[(1R)-1-hydroxy-2-(phosphonooxy)ethyl]-2-oxopyridin-1(2H)-yl]methyl)phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
0.11
-
([3-hydroxy-2-oxo-4-[(phosphonomethoxy)methyl]pyridin-1(2H)-yl]methyl)phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
0.8
-
[[3-hydroxy-2-oxo-4-(2-phosphonoethyl)pyridin-1(2H)-yl]methyl]phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
0.81
-
[2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl]phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
0.9
-
2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl dihydrogen phosphate at pH 7.5 and 25°C Giardia intestinalis
0.97
-
[[(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)methoxy]methyl]phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
1.2
-
[(3-hydroxy-2-oxopyridin-1(2H)-yl)methyl]phosphonic acid at pH 7.5 and 25°C Giardia intestinalis
2.3
-
2-hydroxy-2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl dihydrogen phosphate at pH 7.5 and 25°C Giardia intestinalis