Protein Variants | Comment | Organism |
---|---|---|
K156M | identical to wild type enzyme | Trypanosoma brucei |
K16M | not inhibited by 5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate | Trypanosoma brucei |
K239M | identical to wild type enzyme | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate | 1 mM, 15 min incubation time, 80% residual activity | Oryctolagus cuniculus | |
5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate | 5 mM, 15 min incubation time, no residual activity | Trypanosoma brucei | |
hexitol-1,6-bisphosphate | strong competitive inhibitor | Trypanosoma brucei | |
naphthalene-2,6-bisphosphate | strong competitive inhibitor | Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose 1,6-bisphosphate | - |
Oryctolagus cuniculus | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
D-fructose 1,6-bisphosphate | - |
Trypanosoma brucei | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
dihydroxyacetone phosphate | - |
Oryctolagus cuniculus | ? | - |
? | |
dihydroxyacetone phosphate | - |
Trypanosoma brucei | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
class I fructose 1,6-bisphosphate aldolase | - |
Oryctolagus cuniculus |
class I fructose 1,6-bisphosphate aldolase | - |
Trypanosoma brucei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0233 | - |
5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate | - |
Trypanosoma brucei | |
0.028 | - |
naphthalene-2,6-bisphosphate | - |
Trypanosoma brucei | |
0.045 | - |
hexitol-1,6-bisphosphate | - |
Trypanosoma brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.02 | - |
15 min incubation time | Trypanosoma brucei | 5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate |