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Literature summary for 4.1.2.13 extracted from
- The mechanism of action of aldolases (1968), Adv. Enzymol. Relat. Areas Mol. Biol., 31, 125-181.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | inhibition is fully reversed by a divalent metal ion | Anacystis sp. |  |
| EDTA | inhibition is fully reversed by a divalent metal ion | Aspergillus sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Bacillus sp. (in: Bacteria) | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Brucella sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Candida sp. (in: Saccharomycetales) | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Chlamydomonas sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Clostridium sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Corynebacterium sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Erwinia sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Escherichia coli | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Euglena sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Lactobacillus sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Mycobacterium sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Penicillium sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Pseudomonas sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Saccharomyces sp. | |
| EDTA | inhibition is fully reversed by a divalent metal ion | Veillonella sp. | |
| NaBH4 | metalloaldolases are indifferent | Chlamydomonas sp. | |
| NaBH4 | irreversible inactivation | Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
D-fructose 1,6-bisphosphate | liver | Oryctolagus cuniculus | |
| 0.06 | - |
D-fructose 1,6-bisphosphate | muscle | Oryctolagus cuniculus | |
| 0.3 | - |
D-glyceraldehyde 3-phosphate | liver | Oryctolagus cuniculus | |
| 0.4 | - |
glycerone phosphate | liver | Oryctolagus cuniculus | |
| 0.8 | - |
fructose 1-phosphate | liver | Oryctolagus cuniculus | |
| 1 | - |
D-glyceraldehyde 3-phosphate | muscle | Oryctolagus cuniculus | |
| 2 | - |
glycerone phosphate | muscle | Oryctolagus cuniculus | |
| 10 | - |
fructose 1-phosphate | muscle | Oryctolagus cuniculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | loosely bound Fe2+ or Co2+ | Clostridium sp. | |
| Co2+ | loosely bound Fe2+ or Co2+ | Anacystis sp. | |
| Fe2+ | loosely bound Fe2+ or Co2+ | Clostridium sp. | |
| Fe2+ | loosely bound Fe2+ or Co2+ | Anacystis sp. | |
| K+ | stimulates | Clostridium sp. | |
| K+ | stimulates | Anacystis sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Escherichia coli | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Pseudomonas sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Corynebacterium sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Bacillus sp. (in: Bacteria) | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Mycobacterium sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Lactobacillus sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Chlamydomonas sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Clostridium sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Brucella sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Erwinia sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Veillonella sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Saccharomyces sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Candida sp. (in: Saccharomycetales) | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Aspergillus sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Penicillium sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Anacystis sp. | |
| additional information | metalloaldolase class II, a divalent metal ion is an integral and essential component of the enzyme | Euglena sp. | |
| additional information | class I fructose diphosphate aldolases, Schiff-base forming, does not require a metal ion | Oryctolagus cuniculus | |
| NH4+ | stimulates | Clostridium sp. | |
| NH4+ | stimulates | Anacystis sp. | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 142000 | 160000 | ultracentrifugation experiments | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anacystis sp. | - |
- |
- |
| Aspergillus sp. | - |
- |
- |
| Bacillus sp. (in: Bacteria) | - |
- |
- |
| Brucella sp. | - |
- |
- |
| Candida sp. (in: Saccharomycetales) | - |
- |
- |
| Chlamydomonas sp. | - |
- |
- |
| Clostridium sp. | - |
- |
- |
| Corynebacterium sp. | - |
- |
- |
| Erwinia sp. | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Euglena sp. | - |
- |
- |
| Lactobacillus sp. | - |
- |
- |
| Mycobacterium sp. | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Penicillium sp. | - |
- |
- |
| Pseudomonas sp. | - |
- |
- |
| Saccharomyces sp. | - |
- |
- |
| Veillonella sp. | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate | in class I fructose diphosphate aldolases a Schiff base intermediate is formed between glycerone phosphate or fructose 1,6-diphosphate and an epsilon-amino group of a Lys residue at the active site of the enzyme | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Oryctolagus cuniculus | - |
| muscle | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-bisphosphate | - |
Escherichia coli | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Oryctolagus cuniculus | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Pseudomonas sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Corynebacterium sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Bacillus sp. (in: Bacteria) | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Mycobacterium sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Lactobacillus sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Chlamydomonas sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Clostridium sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Brucella sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Erwinia sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Veillonella sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Saccharomyces sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Candida sp. (in: Saccharomycetales) | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Aspergillus sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Penicillium sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Anacystis sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Euglena sp. | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-Fructose 1-phosphate | - |
Escherichia coli | Glycerone phosphate + D-glyceraldehyde | - |
? | |
| D-Fructose 1-phosphate | - |
Oryctolagus cuniculus | Glycerone phosphate + D-glyceraldehyde | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Escherichia coli | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Oryctolagus cuniculus | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Pseudomonas sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Corynebacterium sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Bacillus sp. (in: Bacteria) | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Mycobacterium sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Lactobacillus sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Chlamydomonas sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Clostridium sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Brucella sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Erwinia sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Veillonella sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Saccharomyces sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Candida sp. (in: Saccharomycetales) | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Aspergillus sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Penicillium sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Anacystis sp. | D-Fructose 1,6-bisphosphate | - |
? | |
| Glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
Euglena sp. | D-Fructose 1,6-bisphosphate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
native enzyme is completely stable | Oryctolagus cuniculus |
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