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Literature summary for 4.1.1.90 extracted from

  • King, C.R.; Deych, E.; Milligan, P.; Eby, C.; Lenzini, P.; Grice, G.; Porche-Sorbet, R.M.; Ridker, P.M.; Gage, B.F.
    Gamma-glutamyl carboxylase and its influence on warfarin dose (2010), Thromb. Haemost., 104, 750-754.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.90

Application

Application Comment Organism
medicine single nucleotide polymorphism in the GGCX gene may affect the dose of warfarin and other vitamin K antagonists Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information GGCX single nucleotide polymorphism rs11676382(but not rs12714145) is a significant predictor of residual warfarin dosing error and is associated with a 6.1% reduction in warfarin dose per G allele Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
-
 Homo sapiens 5789
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + CO2 + O2 + vitamin K hydroquinone Homo sapiens
-
 gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + CO2 + O2 + vitamin K hydroquinone
-
 Homo sapiens gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
gamma-glutamyl carboxylase
-
 Homo sapiens
GGCX
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
vitamin K
-
 Homo sapiens