Application | Comment | Organism |
---|---|---|
medicine | pharmacogenetic studies in patients receiving fluoropyrimidine-based chemotherapy should include genetic variants in dihydropyrimidinase (DPYS) and beta-ureidopropionase (UPB1), in addition to DPYD, to improve the understanding of their contribution to severe toxicity from fluoropyrimidine-based chemotherapy. Potential unknown underlying causal variants linked to the associated dihydropyrimidinase and beta-ureidopropionase variants may have a clinically relevant effect on fluoropyrimidine toxicity and should be investigated | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBR1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-ureidopropanoate + H2O | 3-ureidopropanoate i.e. N-carbamoyl-beta-alanine | Homo sapiens | beta-alanine + CO2 + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UPB1 | - |
Homo sapiens |