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Literature summary for 2.4.1.B74 extracted from

  • Torrelles, J.B.; DesJardin, L.E.; MacNeil, J.; Kaufman, T.M.; Kutzbach, B.; Knaup, R.; McCarthy, T.R.; Gurcha, S.S.; Besra, G.S.; Clegg, S.; Schlesinger, L.S.
    Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death (2009), Glycobiology, 19, 743-755 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine infection of human macrophages by a PimB gene disruption mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WMZ3
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Mycobacterium tuberculosis ATCC 25618 P9WMZ3
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Synonyms

Synonyms Comment Organism
PimB
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 Mycobacterium tuberculosis
Rv0557
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 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function disruption of the PimB gene in a virulent strain does not abolish the production of any of its cell wall mannosylated lipoglycans but results in a quantitative decrease in the lipomannan and mannose-capped lipoarabinomannan content without affecting higher order phosphatidyl-myo-inositol mannosides. Infection of human macrophages by the PimB mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death Mycobacterium tuberculosis