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Literature summary for 2.4.1.344 extracted from

  • Saku, A.; Hirose, K.; Ito, T.; Iwata, A.; Sato, T.; Kaji, H.; Tamachi, T.; Suto, A.; Goto, Y.; Domino, S.; Narimatsu, H.; Kiyono, H.; Nakajima, H.
    Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation (2019), J. Allergy Clin. Immunol., 144, 698-709.e9 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9JL27
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium
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 Mus musculus
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lung
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 Mus musculus
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General Information

General Information Comment Organism
physiological function on allergen inhalation, lung epithelial cells are heavily alpha(1,2)fucosylated by Fut2, which is induced by the IL-13-signal transducer and activator of transcription 6 pathway. Fut2-deficient mice lack lung epithelial fucosylation and show significantly attenuated eosinophilic inflammation and airway hyperresponsiveness in house dust mite-induced asthma models. Complement C3 is accumulated in fucosylated areas. Fut2-/- mice show significantly reduced levels of C3a and impaired accumulation of C3a receptor-expressing monocyte-derived dendritic cells in the lung on house dust mite challenge Mus musculus