Cloned (Comment) | Organism |
---|---|
recombinant expression of EGFP-tagged isozyme HAS1 in MCF-7 cells and localization to the Golgi apparatus | Mus musculus |
recombinant expression of EGFP-tagged isozyme HAS2 in MCF-7 cells and localization to the endoplasmic reticulum | Mus musculus |
recombinant expression of EGFP-tagged isozyme HAS3 in MCF-7 cells and localization to the Golgi apparatus | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
endoplasmic reticulum | isozyme HAS2 has the brightest signal in the endoplasmic reticulum | Mus musculus | 5783 | - |
Golgi apparatus | isozyme HAS1 has the brightest signal in the Golgi network | Mus musculus | 5794 | - |
Golgi apparatus | isozyme HAS3 has the brightest signal in the Golgi and microvillous protrusions | Mus musculus | 5794 | - |
plasma membrane | in natural membrane extensions | Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O08650 | - |
- |
Mus musculus | P70312 | - |
- |
Mus musculus | Q61647 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Mus musculus | - |
embryo | expression of different HAS isoenzymes during embryonic development, overview. Intense hyaluronan staining is observed throughout the development in the tissues of mesodermal origin, like heart and cartilages, but also for example during the maturation of kidneys and stratified epithelia. In general, staining for one or several HAS isozymes correlates with hyaluronan staining. While epithelial cells are mostly negative for HASs, stratified epithelia become HAS positive during differentiation | Mus musculus | - |
embryo | expression of different HAS isoenzymes during embryonic development, overview. Intense hyaluronan staining is observed throughout the development in the tissues of mesodermal origin, like heart and cartilages, but also for example during the maturation of kidneys and stratified epithelia. In general, staining for one or several HAS isozymes correlates with hyaluronan staining. While epithelial cells are mostly negative for HASs, stratified epithelia become HAS positive during differentiation | Mus musculus | - |
epithelium | - |
Mus musculus | - |
fibroblast | skin fibroblast | Mus musculus | - |
HaCaT cell | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
keratinocyte | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
HAS1 | - |
Mus musculus |
Has2 | - |
Mus musculus |
Has3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | the three HAS isoenzymes, HAS1, HAS2, and HAS3, expressed in mammalian cells differ in their enzymatic properties and regulation by external stimuli | Mus musculus |
physiological function | hyaluronan is the largest and one of the most abundant glycosaminoglycans of the extracellular space. Hyaluronan synthases are glycosyltransferases acting on the inner face of plasma membrane, adding alternately glucuronic acid and N-acetylglucosamine to the reducing end of the growing chain. Hyaluronan synthase forms a reserve that is transported to the plasma membrane for rapid activation of hyaluronan synthesis. The levels and localizations of HAS isoforms are likely to be highly important in processes like embryonic development, wound healing, inflammation, and malignant growth | Mus musculus |