Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00219 | isoform HAS3 | - |
Homo sapiens | Q92819 | isoform HAS2 | - |
Homo sapiens | Q92839 | isoform HAS1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
synoviocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Has2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | chondroitin sulfate increases hyaluronan production by osteoarthritic fibroblast-like synoviocytes through up-regulation of the expression of HAS1 and HAS2 associated with activation of ERK-1/2, p38, and Akt, although to a lesser extent. Both p38 and Akt are involved in chondroitin sulfate-induced hyaluronan accumulation. IL-1 increases hyaluronan production and levels of mRNA for HAS1, HAS2, and HAS3. Chondroitin sulfate enhances the IL-1induced level of HAS2 mRNA and reduces the level of HAS3 mRNA. IL-1induced activation of p38 and JNK is slightly decreased by chondroitin sulfate, whereas that of ERK-1/2 and Akt is enhanced. More high molecular weight hyaluronan is found in chondroitin sulfate plus IL-1treated fibroblast-like synoviocytes than in fibroblast-like synoviocytes treated with IL-1 alone | up |