Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C-1748 | mixed-type inhibition of isoform UGT1A9 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60656 | - |
- |
Homo sapiens | O75795 | - |
- |
Homo sapiens | P16662 | - |
- |
Homo sapiens | P22309 | - |
- |
Homo sapiens | P22310 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-29 cell | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-ethyl-10-hydroxy-camptothecin + UDP-glucuronate | i.e SN-38, substrate for isoform UGT1A1 | Homo sapiens | UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronide | - |
? | |
7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate | - |
Homo sapiens | UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide | - |
? | |
C-1748 + UDP-glucuronate | C-1748 is 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine. The reaction is selectively catalyzed by isoform UGT2B17 | Homo sapiens | UDP + C-1748 O-glucuronide | - |
? | |
C-1748 + UDP-glucuronate | C-1748 is 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine. The reaction is selectively catalyzed by isoform UGT2B7 | Homo sapiens | UDP + C-1748 O-glucuronide | - |
? | |
epirubicin + UDP-glucuronate | substrate for isoform UGT2B7 | Homo sapiens | UDP + epirubicin beta-D-glucuronoside | - |
? | |
trifluoperazine dihydrochloride + UDP-glucuronate | substrate for isoform UGT1A4 | Homo sapiens | UDP + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT1A1 | isoform | Homo sapiens |
UGT1A4 | isoform | Homo sapiens |
UGT1A9 | isoform | Homo sapiens |
UGT2B17 | isoform | Homo sapiens |
UGT2B7 | isoform | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.081 | - |
C-1748 | isoform UGT1A9, at pH 7.4 and 37°C | Homo sapiens | |
0.0946 | - |
C-1748 | enzyme from HT-29 cells, at pH 7.4 and 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0397 | - |
isoform UGT1A9, at pH 7.4 and 37°C | Homo sapiens | C-1748 | |
0.0845 | - |
enzyme from HT-29 cells, at pH 7.4 and 37°C | Homo sapiens | C-1748 |