Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Clofibrate | - |
Homo sapiens | |
Digitonin | 0.6 mg/mg liver protein, 1.8fold activation using non-saturated substrate concentration | Homo sapiens | |
Triton X-100 | 0.01%, 1.6fold activation using non-saturated substrate concentration | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-nitrophenol | uncompetitive to chenodeoxycholic acid | Homo sapiens | |
bilirubin | competitive to chenodeoxycholic acid | Homo sapiens | |
chenodeoxycholic acid | inhibits glucuronidation of bilirubin | Homo sapiens | |
Digitonin | inhibition above 0.6 mg/mg protein; no effect at saturating substrate concentrations | Homo sapiens | |
estradiol | competitive to chenodeoxycholic acid | Homo sapiens | |
Fe2+ | - |
Homo sapiens | |
Ni2+ | - |
Homo sapiens | |
testosterone | noncompetitive to chenodeoxycholic acid | Homo sapiens | |
Triton X-100 | above 0.01% v/v; no effect at saturating substrate concentrations | Homo sapiens | |
Zn2+ | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.083 | - |
chenodeoxycholic acid | - |
Homo sapiens | |
0.96 | - |
UDPglucuronic acid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 140% stimulated by 5mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chenodeoxycholic acid + UDP-glucuronate | - |
Homo sapiens | UDP + ? | - |
? | |
cholic acid + UDPglucuronate | - |
Homo sapiens | cholic acid O-glucuronide | - |
? | |
lithocholic acid + UDPglucuronate | - |
Homo sapiens | UDP + ? | - |
? | |
additional information | 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids | Homo sapiens | ? | - |
? | |
additional information | affinity of unconjugated bile acids decrease with increasing number of hydroxyl groups in the bile acid skeleton | Homo sapiens | ? | - |
? | |
ursodeoxycholic acid + UDPglucuronate | - |
Homo sapiens | UDP + ursodeoxycholic acid O-glucuronide | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.7 | - |
chenodeoxycholic acid | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | substrate chenodeoxycholic acid | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.26 | - |
estradiol | - |
Homo sapiens | |
0.28 | - |
bilirubin | - |
Homo sapiens | |
2.2 | - |
testosterone | - |
Homo sapiens |