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Literature summary for 2.3.2.5 extracted from

  • Bender, P.; Egger, A.; Westermann, M.; Taudte, N.; Sculean, A.; Potempa, J.; Moeller, B.; Buchholz, M.; Eick, S.
    Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study (2019), Arch. Oral Biol., 97, 223-230 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.5

Cloned(Commentary)

Cloned (Comment) Organism
real-time PCR enzyme expression analysis Homo sapiens
sequence analysis, real-time PCR enzyme expression analysis Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the isozyme is secreted Homo sapiens
-
-
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutaminyl-peptide Porphyromonas gingivalis
-
 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide Homo sapiens
-
 5-oxoprolyl-peptide + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16769
-
-
Homo sapiens Q9NXS2
-
-
Porphyromonas gingivalis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information expression of Porphyromonas gingivalis enzyme PgQC in human host subgingival biofilm. No enzyme in gingival crevicular fluid Porphyromonas gingivalis
-
additional information isozyme expression analysis in patients with chronic periodontitis (CP) and rheumatoid arthritis (RA), overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutaminyl-monocyte chemoattractant protein 1 i.e. MCP-1 or CCL2 Porphyromonas gingivalis 5-oxoprolyl-monocyte chemoattractant protein 1 + NH3
-
 ?
L-glutaminyl-monocyte chemoattractant protein 1 i.e. MCP-1 or CCL2 Homo sapiens 5-oxoprolyl-monocyte chemoattractant protein 1 + NH3
-
 ?
L-glutaminyl-monocyte chemoattractant protein 3 i.e. MCP-3 or CCL7 Homo sapiens 5-oxoprolyl-monocyte chemoattractant protein 3 + NH3
-
 ?
L-glutaminyl-peptide
-
 Porphyromonas gingivalis 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide
-
 Homo sapiens 5-oxoprolyl-peptide + NH3
-
 ?

Synonyms

Synonyms Comment Organism
glutaminyl cyclase
-
 Porphyromonas gingivalis
glutaminyl cyclase
-
 Homo sapiens
Golgi resident glutaminyl cyclase
-
 Homo sapiens
hQC
-
 Homo sapiens
isoQC
-
 Homo sapiens
PgQC
-
 Porphyromonas gingivalis
secretory glutaminyl cyclase
-
 Homo sapiens
sQC
-
 Homo sapiens

General Information

General Information Comment Organism
additional information enzyme expression analysis in Porphyromonas gingivalis on patients with chronic periodontitis (CP) and rheumatoid arthritis (RA), overview Porphyromonas gingivalis
physiological function glutaminyl cyclase synthesized by Porphyromonas gingivalis (PgQC) is a key pathogen in developing periodontitis, potential link of periodontitis with rheumatoid arthritis (RA) Porphyromonas gingivalis