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Literature summary for 2.3.1.B43 extracted from

  • Park, J.; Chen, Y.; Tishkoff, D.X.; Peng, C.; Tan, M.; Dai, L.; Xie, Z.; Zhang, Y.; Zwaans, B.M.; Skinner, M.E.; Lombard, D.B.; Zhao, Y.
    SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways (2013), Mol. Cell., 50, 919-930.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion SIRT5 is present both mitochondrially and extramitochondrially Mus musculus 5739
-
nucleus a very small amount of SIRT5 is detected in the nuclear fraction Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [pyruvate dehydrogenase complex]-N6-succinyl-L-lysine Mus musculus SIRT5 represses biochemical activity of, and cellular respiration through, the protein complex nicotinamide + [pyruvate dehydrogenase complex]-L-lysine + O-succinyl-ADP-ribose
-
 ?
NAD+ + [succinate dehydrogenase]-N6-succinyl-L-lysine Mus musculus SIRT5 represses biochemical activity of, and cellular respiration through, the protein complex nicotinamide + [succinate dehydrogenase]-L-lysine + O-succinyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K2C6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [pyruvate dehydrogenase complex]-N6-succinyl-L-lysine
-
 Mus musculus nicotinamide + [pyruvate dehydrogenase complex]-L-lysine + O-succinyl-ADP-ribose
-
 ?
NAD+ + [pyruvate dehydrogenase complex]-N6-succinyl-L-lysine SIRT5 represses biochemical activity of, and cellular respiration through, the protein complex Mus musculus nicotinamide + [pyruvate dehydrogenase complex]-L-lysine + O-succinyl-ADP-ribose
-
 ?
NAD+ + [succinate dehydrogenase]-N6-succinyl-L-lysine
-
 Mus musculus nicotinamide + [succinate dehydrogenase]-L-lysine + O-succinyl-ADP-ribose
-
 ?
NAD+ + [succinate dehydrogenase]-N6-succinyl-L-lysine SIRT5 represses biochemical activity of, and cellular respiration through, the protein complex Mus musculus nicotinamide + [succinate dehydrogenase]-L-lysine + O-succinyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
-
 Mus musculus

General Information

General Information Comment Organism
physiological function SIRT5 is a central regulator of Lys succinylation in mammalian cells Mus musculus