Activating Compound | Comment | Organism | Structure |
---|---|---|---|
diethyl maleate | enhanced 3-fold upon treatment with 5 mM H2O2 | Homo sapiens | |
H2O2 | increased in concentration-dependent manner, fast but transitory activation, concentrations of H2O2 ranging from 1 to 10 mM, maximal effect at 10 mM, maximum reached within 20 min | Homo sapiens | |
additional information | membrane-permeable oxidants more effective to provoke synthesis of platelet-activating factor (PAF), no effect on synthesis of platelet-activating factor (PAF) observed in cells treated with 10 mM 2,2'-azobis(2-amidinopropane) dihydrochloride or with 5 mM hydrophobic cumen hydroperoxide | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | i.e. Trolox, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells | Homo sapiens | |
N-acetylcysteine | reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells | Homo sapiens | |
pyrrolidinecarbodithioic acid | i.e. PDTC, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + lyso-platelet-activating factor | Homo sapiens | - |
platelet-activating factor + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q7L5N7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUVEC cell | activity is enhanced in H2O2-treated cells | Homo sapiens | - |
HUVEC cell | H2O2-stimulated | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
exogenous addition of lyso-platelet-activating factor (PAF) without effect on acetyltransferase activity, block of enzyme activity by a tyrosine kinase inhibitor and a calmodulin antagonist in H2O2-stimulated cells suggests involvement of tyrosine kinase and calcium/calmodulin-dependent protein kinase in regulation of enzyme activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + lyso-platelet-activating factor | - |
Homo sapiens | platelet-activating factor + CoA | - |
? | |
acetyl-CoA + lyso-platelet-activating factor | intracellular redox state involved in regulating synthesis of platelet-activating factor (PAF) | Homo sapiens | platelet-activating factor + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase | - |
Homo sapiens |
acetyl-CoA:lysoPAF acetyltransferase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay at | Homo sapiens |