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Literature summary for 2.3.1.57 extracted from

  • Mounce, B.C.; Poirier, E.Z.; Passoni, G.; Simon-Loriere, E.; Cesaro, T.; Prot, M.; Stapleford, K.A.; Moratorio, G.; Sakuntabhai, A.; Levraud, J.P.; Vignuzzi, M.
    Interferon-induced spermidine-spermine acetyltransferase and polyamine depletion restrict Zika and chikungunya viruses (2016), Cell Host Microbe, 20, 167-177 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine Homo sapiens
-
 CoA + N1-acetylspermine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?

Synonyms

Synonyms Comment Organism
SAT1
-
 Homo sapiens
spermidine-spermine acetyltransferase
-
 Homo sapiens
SSAT
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated by type I interferon beta stimulation (10000 units/ml for 16 h) or treatment with N1,N11-diethylnorspermine (0.01 mM for 16 h) up

General Information

General Information Comment Organism
physiological function the enzyme restricts chikungunya virus and Zika virus replication. The enzyme depletes spermidine and spermine to restrict RNA virus replication Homo sapiens