Cloned (Comment) | Organism |
---|---|
SSAT overexpression in prostate cancer cells leads to a massive increase in intracellular and extracellular acetylated spermidine and to a 6-20fold increase in biosynthetic enzyme activities, overview. In the presence of 4-fluoro-ornithine, SSAT overexpression leads to the sequential appearance of fluorinated putrescine, spermidine, acetylated spermidine, and spermine | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 acetyl-CoA + 2 spermine | Homo sapiens | - |
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine | - |
? | |
acetyl-CoA + spermidine | Homo sapiens | - |
CoA + N1-acetylspermidine | - |
? | |
additional information | Homo sapiens | SSAT induction increased metabolic flux by about 5fold, overview. The metabolic flux can be interrupted by inhibition of polyamine biosynthesis but not by inhibition of polyamine oxidation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 acetyl-CoA + 2 spermine | - |
Homo sapiens | 3 CoA + N1-acetylspermine + N1,N12-diacetylspermine | - |
? | |
acetyl-CoA + spermidine | - |
Homo sapiens | CoA + N1-acetylspermidine | - |
? | |
additional information | SSAT induction increased metabolic flux by about 5fold, overview. The metabolic flux can be interrupted by inhibition of polyamine biosynthesis but not by inhibition of polyamine oxidation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase | - |
Homo sapiens |
SSAT | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |