Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
precipitation with polyethylene glycol, high resolution structures of wild-type and mutant SSAT, as the free dimer and in binary and ternary complexes with CoA, acetyl-CoA, spermine, and the inhibitor N1,N11-bis-(ethyl)-norspermine | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N1,N11-bis-(ethyl)-norspermine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | selfacetylation of Lys26 in the presence of acetyl-cCoA and in absence of substrate | Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
dimer | two dimer conformations are observed: a symmetric form with two open surface channels capable of binding substrate or cofactor, and an asymmetric form in which only one of the surface channels appears capable of binding and acetylating polyamines | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase | - |
Homo sapiens |
SSAT | - |
Homo sapiens |