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Literature summary for 2.3.1.43 extracted from

  • Pszenny, V.; Ehrenman, K.; Romano, J.; Kennard, A.; Schultz, A.; Roos, D.; Grigg, M.; Carruthers, V.; Coppens, I.
    A lipolytic lecithin cholesterol acyltransferase secreted by Toxoplasma facilitates parasite replication and egress (2016), J. Biol. Chem., 291, 3725-3746 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.43

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane LCAT is stored in a subpopulation of dense granule secretory organelles, and following secretion, it localizes to the parasitophorous vacuole and parasite plasma membrane Toxoplasma gondii 5886
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secretory vesicle LCAT is stored in a subpopulation of dense granule secretory organelles, and following secretion, it localizes to the parasitophorous vacuole and parasite plasma membrane Toxoplasma gondii 99503
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Organism

Organism UniProt Comment Textmining
Toxoplasma gondii S8GJB1
-
-
Toxoplasma gondii ATCC 50611 S8GJB1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + cholesterol
-
 Toxoplasma gondii cholesteryl ester + lysophosphatidylcholine
-
 ?
phosphatidylcholine + cholesterol
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 Toxoplasma gondii ATCC 50611 cholesteryl ester + lysophosphatidylcholine
-
 ?

Subunits

Subunits Comment Organism
? x * 83000, full-lentgh protein, and x * 62000 + x * 33000, SDS-PAGE, x * 105000, coss-linked species, SDS-PAGE Toxoplasma gondii
More protein is cleaved into two proteolytic fragments that share the residues of the catalytic triad and need to be reassembled to reconstitute enzymatic activity Toxoplasma gondii

Synonyms

Synonyms Comment Organism
TGME49_272420
-
 Toxoplasma gondii

General Information

General Information Comment Organism
physiological function LCAT-null parasites have impaired growth in vitro, reduced virulence in animals, and exhibit delays in egress from host cells. Parasites overexpressing LCAT show increased virulence and faster egress Toxoplasma gondii