Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | association of Apo AI with HDLs activates LCAT activity, molecular mechanism, conformational changes in several exposed regions of Apo-AI might cause enzyyme LCAT activation. Apo AI-derived peptides display a disordered arrangement, with a strong tendency to adopt beta-sheet and random conformational structures as a function of concentration, but in the presence of lyso-C12-phosphocholine, maximal percentages of alpha-helical structures are observed | Homo sapiens | |
additional information | peptides, initially present in a disordered conformation, are able to sense the lipid environment provided by lipoproteins of plasma and following a disorder-to-order transition, change their conformation to an ordered alpha-helix | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + a sterol | Homo sapiens | - |
1-acylglycerophosphocholine + a sterol ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04180 | gene lcat | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme activities with apolipoprotein A-I and Apo AI-derived peptides DRV, KLL, and VLES, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + a sterol | - |
Homo sapiens | 1-acylglycerophosphocholine + a sterol ester | - |
? | |
phosphatidylcholine + a sterol | enzyme activities with apolipoprotein A-I and Apo AI-derived peptides DRV, KLL, and VLES, overview | Homo sapiens | 1-acylglycerophosphocholine + a sterol ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
lecithin cholesterol acyltransferase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |