Application | Comment | Organism |
---|---|---|
medicine | the correction of the aberrant HDL phenotypes by treatment with LCAT suggests a potential therapeutic intervention for HDL abnormalities that result from specific mutations in apoA-I | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | using adenovirus-mediated gene transfer of the mutants apoA-I(R151C), apoA-I(R160L) and apoA-I(R149A) in apoA-I-/- mice, a common feature of the three mutations are observed: low HDL levels and the presence of discoidal particles in plasma. These defects can be corrected by coinfection of apoA-I-/- mice with adenoviruses expressing the mutant proteins along with human LCAT, indicating that the endogenous LCAT is rate limiting in the conversion of discoidal into spherical HDL | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
lecithin-cholesterol acyltransferase | - |
Homo sapiens |