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Literature summary for 2.3.1.42 extracted from
- Amplification of glyceronephosphate O-acyltransferase and recruitment of USP30 stabilize DRP1 to promote hepatocarcinogenesis (2018), Cancer Res., 78, 5808-5819 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is highly correlated with poor clinical outcome in patients with hepatocellular carcinoma | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Homo sapiens | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + glycerone phosphate | Homo sapiens | - |
CoA + acylglycerone phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O15228 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BEL-7402 cell | - |
Homo sapiens | - |
| FHCC-98 cell | - |
Homo sapiens | - |
| HCCLM-9 cell | - |
Homo sapiens | - |
| HEP-3B cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| hepatoma cell | - |
Homo sapiens | - |
| HL-7702 cell | - |
Homo sapiens | - |
| Huh-7 cell | - |
Homo sapiens | - |
| MHCC97-L cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + glycerone phosphate | - |
Homo sapiens | CoA + acylglycerone phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 70000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glyceronephosphate O-acyltransferase | - |
Homo sapiens |
| GNPAT | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the enzyme is upregulated in patients with hepatocellular carcinoma | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme recruits the enzyme USP30, which deubiquitylates and stabilizes dynamin-related protein 1, thereby facilitating regulation of mitochondrial morphology, lipid metabolism, and hepatocarcinogenesis | Homo sapiens |
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Release 2023.1 (January 2023)
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