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Literature summary for 2.3.1.297 extracted from

  • Park, W.J.; Brenner, O.; Kogot-Levin, A.; Saada, A.; Merrill, A.H.; Pewzner-Jung, Y.; Futerman, A.H.
    Development of pheochromocytoma in ceramide synthase 2 null mice (2015), Endocr. Relat. Cancer, 22, 623-632 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a very-long-chain fatty acyl-CoA + a sphingoid base Mus musculus the enzyme synthesizes ceramides with very-long (C22-C24) acyl chains a very-long-chain ceramide + CoA
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a very-long-chain fatty acyl-CoA + a sphingoid base the enzyme synthesizes ceramides with very-long (C22-C24) acyl chains Mus musculus a very-long-chain ceramide + CoA
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 ?

Synonyms

Synonyms Comment Organism
ceramide synthase 2
-
 Mus musculus
CerS2
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 Mus musculus

General Information

General Information Comment Organism
malfunction about 50% of enzyme-null mice develop pheochromocytoma by about 13 months, and the rest shows signs of medullary hyperplasia Mus musculus