Application | Comment | Organism |
---|---|---|
synthesis | de novo production of noscapine in Saccharomyces cerevisiae, through the reconstruction of a biosynthetic pathway comprising over 30 enzymes from plants, bacteria, mammals, and yeast itself. Optimization of conditions leads to an over 18,000fold improvement from initial noscapine titers to about2.2 mg/l. By feeding modified tyrosine derivatives to the optimized noscapine-producing strain, microbial production of halogenated benzylisoquinoline alkaloids is possible | Papaver somniferum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Papaver somniferum | I3PLR4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + (13S,14R)-1,13-dihydroxy-N-methylcanadine | - |
Papaver somniferum | (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA | - |
? |