Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | A0A0H2Z7U1 | cf. EC 2.3.1.180 | - |
Pseudomonas aeruginosa UCBPP-PA14 | A0A0H2Z7U1 | cf. EC 2.3.1.180 | - |
Synonyms | Comment | Organism |
---|---|---|
PqsD | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
physiological function | 4-hydroxy-2-alkylquinoline biosynthesis, which requires the PqsABCD enzymes, proceeds by a two-step pathway: PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-coenzyme A and malonyl-coenzyme A, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of 3,4-dihydroxy-2-heptylquinoline. PqsB is tightly associated with PqsC and required for the second step. None of the pqsA-, pqsB-, pqsC-, and pqs- mutants produces measurable amounts of 4-hydroxy-2-alkylquinolines | Pseudomonas aeruginosa |