Literature summary for 2.3.1.203 extracted from

De Schutter, J.; Morrison, J.; Morrison, M.; Ciulli, A.; Imperiali, B.
Targeting bacillosamine biosynthesis in bacterial pathogens Development of inhibitors to a bacterial amino-sugar acetyltransferase from Campylobacter jejuni (2017), J. Med. Chem., 60, 2099-2118 .

Search for more literature for 2.3.1.203

Application

Application	Comment	Organism
drug development	development of a new series of thienopyrimidine-6-carboxylate inhibitors of the Campylobacter jejuni PglD UDP-amino-sugar acetyltransferase enzyme, which upon further optimization may lead to new agents with targeted antivirulence activity	Campylobacter jejuni subsp. jejuni

Cloned(Commentary)

Cloned (Comment)	Organism
heterologous expression in Escherichia coli BL-21(DE3)	Campylobacter jejuni subsp. jejuni

Inhibitors

Inhibitors	Comment	Organism
2-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-methyl-4-(methylamino)-thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(2-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(3-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(3-chlorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(3-fluorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(3-methoxyphenethyl)-4-(methylamino)thieno[3,2-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(3-methoxyphenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(4-acetamidophenethyl)-4-((2-aminoethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(4-acetamidophenethyl)-5-methyl-4-((2-(pyridin-2-yl)ethyl)-amino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
2-(4-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-( (2,3-dihydro-1H-inden-2-yl )amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((2-aminoethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((2-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((2-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((3,5-dimethoxyphenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((3-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((3-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((4-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-((4-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-(benzylamino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
4-(methylamino)-2-phenethylthieno[3,2-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-2-phenethyl-4-((2-(pyridin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-2-phenethyl-4-((2-(pyridin-3-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-2-phenethyl-4-((2-(pyridin-4-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-2-phenethyl-4-(phenethylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-((2-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-((3-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-((4-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-(methylamino)-2-(2-(pyridin-2-yl)ethyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-(methylamino)-2-(3-(trifluoromethyl)phenethyl)-thieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-(methylamino)-2-(3-phenylpropyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-(methylamino)-2-(4-phenylbutyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid	-	Campylobacter jejuni subsp. jejuni
ethyl (S)-2-(4-acetamidophenethyl)-4-((2-methoxy-2-phenylethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate	-	Campylobacter jejuni subsp. jejuni
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate	-	Campylobacter jejuni subsp. jejuni
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate	-	Campylobacter jejuni subsp. jejuni
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate	-	Campylobacter jejuni subsp. jejuni
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate	-	Campylobacter jejuni subsp. jejuni

Organism

Organism	UniProt	Comment	Textmining
Campylobacter jejuni subsp. jejuni	Q0P9D1	-	-
Campylobacter jejuni subsp. jejuni NCTC 11168	Q0P9D1	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Campylobacter jejuni subsp. jejuni

Synonyms

Synonyms	Comment	Organism
PglD	-	Campylobacter jejuni subsp. jejuni

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.00025	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-((2-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00027	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	ethyl (S)-2-(4-acetamidophenethyl)-4-((2-methoxy-2-phenylethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
0.00028	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(4-acetamidophenethyl)-5-methyl-4-((2-(pyridin-2-yl)ethyl)-amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
0.00034	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-2-phenethyl-4-((2-(pyridin-3-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
0.00037	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((3,5-dimethoxyphenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00039	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((3-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00039	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-2-phenethyl-4-((2-(pyridin-4-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
0.00042	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((4-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00042	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-((3-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00042	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-2-phenethyl-4-((2-(pyridin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
0.00042	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
0.00045	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((3-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
0.00046	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-(methylamino)-2-(2-(pyridin-2-yl)ethyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
0.00048	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((2-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
0.00048	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((2-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00054	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((4-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
0.00059	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00072	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-((4-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.00087	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
0.001	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-( (2,3-dihydro-1H-inden-2-yl )amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.0011	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(3-methoxyphenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
0.0011	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
0.0014	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-2-phenethyl-4-(phenethylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
0.0014	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(4-acetamidophenethyl)-4-((2-aminoethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.0014	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(3-methoxyphenethyl)-4-(methylamino)thieno[3,2-d]-pyrimidine-6-carboxylic acid
0.0016	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-((2-aminoethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]-pyrimidine-6-carboxylic acid
0.0018	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-methyl-4-(methylamino)-thieno[2,3-d]pyrimidine-6-carboxylic acid
0.002	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
0.0021	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(3-chlorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
0.0022	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.0023	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(3-fluorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
0.0024	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(4-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
0.0035	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(3-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
0.0039	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-(methylamino)-2-phenethylthieno[3,2-d]pyrimidine-6-carboxylic acid
0.0041	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-(methylamino)-2-(4-phenylbutyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
0.0044	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-(methylamino)-2-(3-phenylpropyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
0.0045	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	4-(benzylamino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
0.0046	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	5-methyl-4-(methylamino)-2-(3-(trifluoromethyl)phenethyl)-thieno[2,3-d]pyrimidine-6-carboxylic acid
0.009	-	pH 7.8, temperature not specified in the publication	Campylobacter jejuni subsp. jejuni	2-(2-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid