Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8K341 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | primary mouse cortical neuron | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ATAT1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | exposure of primary mouse cortical neurons to soluble chondroitin sulfate proteoglycans and myelin-associated glycoprotein substrates causes an acute and RhoA-kinase-dependent reduction in alpha-tubulin acetylation and Atat1 protein levels, without changes to either axonal histone deacetylase-6 levels or histonedeacetylase-6 activity. The chondroitin sulfate proteoglycans and myelin-associated glycoprotein-induced reduction in Atat1 occurs primarily in the distal and middle regions of neurites and reconstitution of Atat1, either by Rho-associated kinase inhibition or lentiviral-mediated Atat1 overexpression, can restore neurite growth. Chondroitin sulfate proteoglycans and myelin-associated glycoprotein signaling decreases Atat1 levels posttranscriptionally via a Rho-associated kinase-dependent increase in Atat1 protein turnover | Mus musculus |