Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.79 extracted from

  • Jiang, X.; Duan, Y.; Zhou, B.; Guo, Q.; Wang, H.; Hang, X.; Zeng, L.; Jia, J.; Bi, H.
    The cyclopropane fatty acid synthase mediates antibiotic resistance and gastric colonization of Helicobacter pylori (2019), J. Bacteriol., 201, e00374-19 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.79

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta(DE3) cells Helicobacter pylori

Inhibitors

Inhibitors Comment Organism Structure
dioctylamine substrate mimic Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + phospholipid olefinic fatty acid Helicobacter pylori
-
 S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
 ?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid Helicobacter pylori 26695
-
 S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Helicobacter pylori 26695
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel-ion affinity column chromatography Helicobacter pylori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
-
 Helicobacter pylori S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
 ?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
-
 Helicobacter pylori 26695 S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
 ?

Subunits

Subunits Comment Organism
? x * 45400, calculated from amino acid sequence Helicobacter pylori

Synonyms

Synonyms Comment Organism
CFAS
-
 Helicobacter pylori
cyclopropane fatty acid synthase
-
 Helicobacter pylori
HP0416
-
 Helicobacter pylori

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.06381
-
 at pH 7.5 and 37°C Helicobacter pylori dioctylamine

General Information

General Information Comment Organism
malfunction enzyme inhibition results into sensitivity to acid stress, increased antibiotic susceptibility, and attenuated abilities to avoid macrophage killing and to colonize mouse stomachs Helicobacter pylori
physiological function the enzyme is required for acid resistance, antibiotic resistance, intracellular survival and mouse gastric colonization, and cell membrane integrity Helicobacter pylori