Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of GNMT knockout mice, knockout mice have elevated serum aminotransferase, methionine, and S-adenosyl-L-methionine levels and develop liver steatosis, fibrosis, and hepatocellular carcinoma, loss of GNMT induces aberrant methylation of DNA and histones, resulting in epigenetic modulation of critical carcinogenic pathways, several Ras and JAK/STAT inhibitors are reduced in liver tumors of enzyme knockout mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | major folate binding protein | ? | - |
? | |
S-adenosyl-L-methionine + glycine | Mus musculus | key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine | S-adenosyl-L-homocysteine + N-methylglycine | N-methylglycine = sarcosine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male, construction of GNMT knockout mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | normal liver, not present in hepatocellular carcinoma | Mus musculus | - |
pancreas | - |
Mus musculus | - |
prostate | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | major folate binding protein | Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + glycine | key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine | Mus musculus | S-adenosyl-L-homocysteine + N-methylglycine | N-methylglycine = sarcosine | ? |
Synonyms | Comment | Organism |
---|---|---|
GNMT | - |
Mus musculus |