Literature summary for 2.1.1.148 extracted from

Skouloubris, S.; Djaout, K.; Lamarre, I.; Lambry, J.C.; Anger, K.; Briffotaux, J.; Liebl, U.; de Reuse, H.; Myllykallio, H.
Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones (2015), Open Biology, 5, 150015 .

Search for more literature for 2.1.1.148

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Helicobacter pylori

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(furan-2-yl)-3-hydroxynaphthalene-1,4-dione	inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro	Helicobacter pylori
2-hydroxy-3-(4-methoxyphenyl)naphthalene-1,4-dione	inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro	Helicobacter pylori
2-hydroxy-3-propylnaphthalene-1,4-dione	inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro, significant decrease of 1.22 log (17fold) in the colonization loads with Helicobacter pylori of mice treated with the molecule	Helicobacter pylori
2-[4-fluoro-3-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-1,4-dione	inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	O26061	-	-
Helicobacter pylori 26695	O26061	-	-

Synonyms

Synonyms	Comment	Organism
ThyX	-	Helicobacter pylori

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000028	-	2-(furan-2-yl)-3-hydroxynaphthalene-1,4-dione	pH 8.0, 37°C	Helicobacter pylori
0.000258	-	2-hydroxy-3-propylnaphthalene-1,4-dione	pH 8.0, 37°C	Helicobacter pylori
0.000367	-	2-hydroxy-3-(4-methoxyphenyl)naphthalene-1,4-dione	pH 8.0, 37°C	Helicobacter pylori
0.001	-	2-[4-fluoro-3-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-1,4-dione	pH 8.0, 37°C	Helicobacter pylori

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Release 2023.1 (January 2023)