Protein Variants | Comment | Organism |
---|---|---|
A177P | the mutant shows 0.6% of wild type activity | Homo sapiens |
A279V | the mutant shows 22.9% of wild type activity | Homo sapiens |
R349W | the mutant shows 0.5% of wild type activity | Homo sapiens |
W179S | the mutant shows 2.7% of wild type activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [sulfatase]-L-cysteine + O2 + a thiol | Homo sapiens | - |
a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NBK3 | - |
- |
Purification (Comment) | Organism |
---|---|
MonoQ column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-1080 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [sulfatase]-L-cysteine + O2 + a thiol | - |
Homo sapiens | a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 38000, secreted enzyme, SDS-PAGE | Homo sapiens |
? | x * 41000, full-length enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
FGE | - |
Homo sapiens |
SUMF1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | multiple sulfatase deficiency is caused by mutations in the SUMF1 gene encoding the formylglycine-generating enzyme | Homo sapiens |
metabolism | the enzyme posttranslationally activates sulfatases by generating formylglycine in their catalytic sites | Homo sapiens |