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Literature summary for 1.8.3.7 extracted from
- Sulfotransferases, sulfatases and formylglycine-generating enzymes a sulfation fascination (2008), Curr. Opin. Chem. Biol., 12, 573-581 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [sulfatase]-L-cysteine + O2 + a thiol | Homo sapiens | - |
a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [sulfatase]-L-cysteine + O2 + a thiol | - |
Homo sapiens | a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FGE | - |
Homo sapiens |
| SUMF1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme is cofactor-independent | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme dysfunction causes a lysosomal storage disorder known as multiple sulfatase deficiency, where all sulfatases either lack or suffer from a severely reduced, catalytic activity caused by incomplete generation of formylglycine | Homo sapiens |
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