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Literature summary for 1.5.1.3 extracted from
- Dihydrofolate reductase is a valid target for antifungal development in the human pathogen Candida albicans (2020), mSphere, 5, e00374 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | P22906 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DFR1 | - |
Candida albicans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | DHFR is essential for growth in vitro. Nutritional supplements of most forms of folate are not sufficient to restore growth when DHFR expression is suppressed or when its activity is directly inhibited by methotrexate. A strain with doxycycline-repressible expression of DHFR is rendered avirulent in a mouse model of disseminated candidiasis upon doxycycline treatment | Candida albicans |
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Release 2023.1 (January 2023)
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