Literature summary for 1.5.1.3 extracted from

Kaur, S.; Bhattacharyya, R.; Banerjee, D.
Hydrochlorothiazide and indapamide bind the NADPH binding site of bacterial dihydrofolate reductase results of an in-silico study and their implications (2020), In Silico Pharmacol., 8, 005 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
modeling of complexes with inhibitors hydrochlorothiazide and indapamide. Compared to the DHFR-ethacrynic acid complex, DHFR-sulphadiazine, DHFR-indapamide, and DHFR-hydrochlorothiazide complexes have higher negative binding energies. The compounds may act similar to antibiotics from the perspective of binding with DHFR	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
hydrochlorothiazide	sulfonamide diuretic, able to bind to DHFR	Escherichia coli
indapamide	sulfonamide diuretic, able to bind to DHFR	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0ABQ4	-	-

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Release 2023.1 (January 2023)