Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00374 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | - |
Homo sapiens | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme displays a kinetic isotope effect KIE (kHLE/kHHE) close to unity above 0°C. The enzyme KIE is increased to 1.720 at -20°C, The coupling of protein motions to the chemical step may be minimized under optimal conditions but enhanced at non-physiological temperatures | Homo sapiens |