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Literature summary for 1.5.1.3 extracted from

  • Mueller, L.; Hauser, P.; Gauye, F.; Greub, G.
    Lausannevirus encodes a functional dihydrofolate reductase susceptible to proguanil (2017), Antimicrob. Agents Chemother., 61, e02573 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Lausannevirus

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: trimethoprim and pyrimethamine Lausannevirus
proguanil
-
 Lausannevirus

Organism

Organism UniProt Comment Textmining
Lausannevirus F2WM04 bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
-

Synonyms

Synonyms Comment Organism
LAU_0427
-
 Lausannevirus

General Information

General Information Comment Organism
physiological function enzyme is able to complement a Saccharomyces cerevisiae DHFR mutant strain Lausannevirus