Literature summary for 1.5.1.3 extracted from

Ribeiro, J.; Chavez-Pacheco, S.; De Oliveira, G.; Dos Santos Silva, C.; Giudice, J.; Libreros-Zuniga, G.; Dias, M.
Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates (2019), Acta Crystallogr. D Struct. Biol., 75, 682-693 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment)	Organism
structures of dihydrofolate reductase in complex with antifolates, pyrimethamine, cycloguanil, diaverdine and pemetrexed, and with substrate dihydrofolate. The structures of all complexes are obtained in the closed-conformation state of the enzyme and motion in key regions of the substrate-binding site and different binding modes of the ligands are observed	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WNX1	-	-
Mycobacterium tuberculosis ATCC 25618	P9WNX1	-	-

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Release 2023.1 (January 2023)