Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | - |
Mycobacterium avium | |
(2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | - |
Pneumocystis carinii | |
(2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | - |
Rattus norvegicus | |
(2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | - |
Toxoplasma gondii | |
3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | - |
Mycobacterium avium | |
3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | - |
Pneumocystis carinii | |
3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | - |
Rattus norvegicus | |
3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | - |
Toxoplasma gondii | |
3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | - |
Mycobacterium avium | |
3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | - |
Pneumocystis carinii | |
3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | - |
Rattus norvegicus | |
3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | - |
Toxoplasma gondii | |
5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | - |
Toxoplasma gondii | |
5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | - |
Toxoplasma gondii | |
5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | - |
Toxoplasma gondii | |
5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | - |
Toxoplasma gondii | |
5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | - |
Toxoplasma gondii | |
5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | - |
Toxoplasma gondii | |
6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Mycobacterium avium | |
6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Pneumocystis carinii | |
6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Rattus norvegicus | |
6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Toxoplasma gondii | |
6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Mycobacterium avium | |
6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Pneumocystis carinii | |
6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Rattus norvegicus | |
6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Toxoplasma gondii | |
6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Mycobacterium avium | |
6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Pneumocystis carinii | |
6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Rattus norvegicus | |
6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | - |
Toxoplasma gondii | |
6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | - |
Toxoplasma gondii | |
6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | - |
Mycobacterium avium | |
6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | - |
Pneumocystis carinii | |
6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | - |
Rattus norvegicus | |
6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | - |
Toxoplasma gondii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium avium | - |
- |
- |
Pneumocystis carinii | P16184 | - |
- |
Rattus norvegicus | - |
- |
- |
Toxoplasma gondii | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
DHFR | - |
Rattus norvegicus |
DHFR | - |
Mycobacterium avium |
DHFR | - |
Toxoplasma gondii |
DHFR | - |
Pneumocystis carinii |
dihydrofolate reductase | - |
Rattus norvegicus |
dihydrofolate reductase | - |
Mycobacterium avium |
dihydrofolate reductase | - |
Toxoplasma gondii |
dihydrofolate reductase | - |
Pneumocystis carinii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Mycobacterium avium |
37 | - |
assay at | Toxoplasma gondii |
37 | - |
assay at | Pneumocystis carinii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00011 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | |
0.00014 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | |
0.00084 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | |
0.00088 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | |
0.0016 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 5-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-pyrimidine-2,4-diamine | |
0.00233 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | |
0.00335 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | |
0.0034 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | |
0.006 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | |
0.0078 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | (2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | |
0.008 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | |
0.011 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | |
0.011 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | |
0.022 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | |
0.023 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | |
0.026 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | |
0.035 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | |
0.038 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | |
0.044 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | |
0.044 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | |
0.044 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | |
0.079 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | |
0.112 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | |
0.116 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | |
0.117 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.117 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.119 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | |
0.124 | - |
37°C, pH not specified in the publication | Rattus norvegicus | (2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | |
0.124 | - |
37°C, pH not specified in the publication | Mycobacterium avium | (2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | |
0.124 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | (2,4-diaminopyrimidin-5-yl)methyl naphthalene-2-sulfonate | |
0.127 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | |
0.127 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | |
0.13 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 5-((5H-dibenzo[b,f]azepin-5-yl)methyl)pyrimidine-2,4-diamine | |
0.138 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.139 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.139 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.142 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.142 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.142 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.145 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | |
0.145 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | |
0.148 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 6-(3,4,5-trimethoxybenzyloxy)pyrimidine-2,4-diamine | |
0.15 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 5-((naphthalen-1-ylamino)methyl)pyrimidine-2,4-diamine | |
0.151 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | |
0.151 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | |
0.151 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 3-(2,4-diaminopyrimidin-5-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one | |
0.16 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | |
0.178 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 3-(2,4-diaminophenyl)-1-(3-(4-methylbenzyloxy)phenyl)prop-2-en-1-one | |
0.18 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 6-(2-(5H-dibenzo[b,f]azepin-5-yl)ethoxy)pyrimidine-2,4-diamine | |
0.184 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 5-((methyl(naphthalen-1-yl)amino)methyl)pyrimidine-2,4-diamine | |
0.235 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 6-((10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.363 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 5-((4-methoxyphenylamino)methyl)pyrimidine-2,4-diamine | |
0.397 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
0.52 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 5-((benzo[d]oxazol-2-ylthio)methyl)pyrimidine-2,4-diamine | |
0.603 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 6-((2-chloro-10H-phenothiazin-10-yl)methyl)-1,3,5-triazine-2,4-diamine | |
1.265 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 6-((10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)methyl)-1,3,5-triazine-2,4-diamine |