Application | Comment | Organism |
---|---|---|
drug development | enzyme is identical to enzyme from Bacillus anthracis. Use of enzyme as antimicrobial target for Bacillus anthracis, homology modelling of inhibitors and growth inhibition assays | Bacillus cereus |
drug development | enzyme is identical to enzyme from Bacillus cereus. Use of enzyme from Bacillus cereus as antimicrobial target for Bacillus anthracis, homology modelling of inhibitors and growth inhibition assays | Bacillus anthracis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]butanoic acid | 50% inhibition of growth in culture at 0.00060 mM | Bacillus cereus | |
5-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]pentanoic acid | 50% inhibition of growth in culture at 0.00167 mM | Bacillus cereus | |
6-([(2-bromo-3,4,5-trimethoxyphenyl)amino]methyl)quinazoline-2,4-diamine | 50% inhibition of growth in culture at 0.0011 mM | Bacillus cereus | |
6-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]hexanoic acid | 50% inhibition of growth in culture at 0.00051 mM | Bacillus cereus | |
6-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl]hex-5-ynoic acid | 50% inhibition of growth in culture at 0.00190 mM | Bacillus cereus | |
7-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl]hept-6-ynoic acid | 50% inhibition of growth in culture at 0.000027 mM | Bacillus cereus | |
ethyl 4-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]butanoate | 50% inhibition of growth in culture at 0.00088 mM | Bacillus cereus | |
ethyl 5-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]pentanoate | 50% inhibition of growth in culture at 0.00035 mM | Bacillus cereus | |
ethyl 6-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]hexanoate | 50% inhibition of growth in culture at 0.00185 mM | Bacillus cereus | |
N-[(4-[[(2,4-diaminopteridin-6-yl)methyl](methyl)amino]phenyl)carbonyl]glutamic acid | 50% inhibition of growth in culture at 0.000024 mM | Bacillus cereus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | Q81R22 | - |
- |
Bacillus cereus | Q81E04 | - |
- |