Inhibitors | Comment | Organism | Structure |
---|---|---|---|
folate | at 0.1 mM | Crithidia fasciculata | |
folate | at 0.1 mM | Strigomonas oncopelti | |
methotrexate | - |
Crithidia fasciculata | |
methotrexate | - |
Strigomonas oncopelti | |
additional information | no effect of biopterin and dihydrobiopterin at 0.1 mM; overview | Crithidia fasciculata | |
additional information | no effect of biopterin and dihydrobiopterin at 0.1 mM; overview | Strigomonas oncopelti | |
pyrimethamine | - |
Crithidia fasciculata | |
pyrimethamine | - |
Strigomonas oncopelti | |
trimethoprim | - |
Crithidia fasciculata | |
trimethoprim | - |
Strigomonas oncopelti |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Crithidia fasciculata | |
additional information | - |
additional information | - |
Strigomonas oncopelti | |
0.003 | - |
7,8-dihydrofolate | - |
Crithidia fasciculata | |
0.003 | - |
7,8-dihydrofolate | - |
Strigomonas oncopelti | |
0.05 | - |
NADPH | - |
Crithidia fasciculata | |
0.05 | - |
NADPH | - |
Strigomonas oncopelti |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Strigomonas oncopelti | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH | - |
Crithidia fasciculata | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | - |
Strigomonas oncopelti | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
folate + NADPH | no activity | Crithidia fasciculata | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
folate + NADPH | no activity | Strigomonas oncopelti | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
additional information | no activity with 7,8-dihydrobiopterin and biopterin | Crithidia fasciculata | ? | - |
? | |
additional information | no activity with 7,8-dihydrobiopterin and biopterin | Strigomonas oncopelti | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 7 | - |
Crithidia fasciculata |
6 | 7 | - |
Strigomonas oncopelti |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 8.8 | half-maximal activities at pH 5.5 and pH 8.8 | Crithidia fasciculata |
5.5 | 7.8 | half-maximal activities at pH 5.5 and pH 7.8 | Strigomonas oncopelti |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | not | Crithidia fasciculata | |
NADH | not | Strigomonas oncopelti |